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Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

Brown, Guy C. Neher, Jonas J.

Inflammatory neurodegeneration contributes to a wide variety of brain pathologies. A number of mechanisms by which inflammatory-activated microglia and astrocytes kill neurons have been identified in culture. These include: (1) acute activation of the phagocyte NADPH oxidase (PHOX) found in microglia, (2) expression of the inducible nitric oxide sy...

Can specialized pathogens colonize distantly related hosts? Schistosome evolution as a case study.

Brant, Sara V Loker, Eric S

Published in PLoS pathogens

Coping with multiple virulence factors: which is most important?

McClelland, Erin E Bernhardt, Paul Casadevall, Arturo

Published in PLoS pathogens

A new Bacillus anthracis found in wild chimpanzees and a gorilla from West and Central Africa.

Leendertz, Fabian H Yumlu, Saniye Pauli, Georg Boesch, Christophe Couacy-Hymann, Emmanuel Vigilant, Linda Junglen, Sandra Schenk, Svenja Ellerbrok, Heinz

Published in PLoS pathogens

The scientific response to a pandemic.

Gronvall, Gigi Kwik Waldhorn, Richard E Henderson, D A

Published in PLoS pathogens

Modulation of tumor necrosis factor by microbial pathogens.

Rahman, Masmudur M McFadden, Grant

Published in PLoS pathogens

In response to invasion by microbial pathogens, host defense mechanisms get activated by both the innate and adaptive arms of the immune responses. TNF (tumor necrosis factor) is a potent proinflammatory cytokine expressed by activated macrophages and lymphocytes that induces diverse cellular responses that can vary from apoptosis to the expression...

Functional and Genetic Analysis of Coronavirus Replicase-Transcriptase Proteins

Sawicki, Stanley G Sawicki, Dorothea L Younker, Diane Meyer, Yvonne Thiel, Volker Stokes, Helen Siddell, Stuart G

Published in PLoS Pathogens

The expanding universe of prion diseases.

Watts, Joel C Balachandran, Aru Westaway, David

Published in PLoS pathogens

Prions cause fatal and transmissible neurodegenerative disease. These etiological infectious agents are formed in greater part from a misfolded cell-surface protein called PrP(C). Several mammalian species are affected by the diseases, and in the case of "mad cow disease" (BSE) the agent has a tropism for humans, with negative consequences for agri...

The integration hypothesis: an evolutionary pathway to benign SIV infection.

Müller, Viktor De Boer, Rob J

Published in PLoS pathogens

The Acetobacteraceae: extending the spectrum of human pathogens.

Fredricks, David Ramakrishnan, Lalita

Published in PLoS pathogens

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