Nouda, Ryotaro Kawagishi, Takahiro Kanai, Yuta Shimojima, Masayuki Saijo, Masayuki Matsuura, Yoshiharu Kobayashi, Takeshi
Published in
PLoS Pathogens
Bat-borne viruses including the severe acute respiratory syndrome coronavirus and Nipah virus generally cause highly pathogenic diseases in humans but not in their bat reservoirs. Nelson Bay orthoreovirus (NBV), a bat-borne virus associated with acute respiratory tract infections in humans, possesses two unique nonstructural proteins, FAST and p17....
Ning, Kang Wang, Zekun Cheng, Fang Yan, Ziying Qiu, Jianming
Published in
PLoS Pathogens
HBoV1, an autonomously replicating human parvovirus, causes acute respiratory tract infections in young children. HBoV1 infects and productively replicates in non-dividing (well-differentiated) cells of HAE-ALI. HBoV1 replication induces a DNA damage response and activates DNA repair, which drive viral genome amplification. In this report, we ident...
Gu, Feng Wang, Chong Wei, Fang Wang, Yuyan Zhu, Qing Ding, Ling Xu, Wenjia Zhu, Caixia Cai, Cankun Qian, Zhikang
...
Published in
PLoS pathogens
[This corrects the article DOI: 10.1371/journal.ppat.1007416.].
Hodcroft, Emma B Dyrdak, Robert Andrés, Cristina Egli, Adrian Reist, Josiane García Martínez de Artola, Diego Alcoba-Flórez, Julia Niesters, Hubert G M Antón, Andrés Poelman, Randy
...
Published in
PLoS pathogens
Worldwide outbreaks of enterovirus D68 (EV-D68) in 2014 and 2016 have caused serious respiratory and neurological disease. We collected samples from several European countries during the 2018 outbreak and determined 53 near full-length genome ('whole genome') sequences. These sequences were combined with 718 whole genome and 1,987 VP1-gene publicly...
Hemara, Lauren M. Jayaraman, Jay Sutherland, Paul W. Montefiori, Mirco Arshed, Saadiah Chatterjee, Abhishek Chen, Ronan Andersen, Mark T. Mesarich, Carl H. van der Linden, Otto
...
Published in
PLoS Pathogens
Clonally propagated monoculture crop plants facilitate the emergence and spread of new diseases. Plant pathogens cause disease by the secretion of effectors that function by repressing the host defense response. While the last few decades have seen a huge increase in our understanding of the role effectors play in mediating plant-pathogen interacti...
Han, Mingyu Cantaloube-Ferrieu, Vincent Xie, Maorong Armani-Tourret, Marie Woottum, Marie Pagès, Jean-Christophe Colin, Philippe Lagane, Bernard Benichou, Serge
Published in
PLoS Pathogens
Understanding how HIV-1 hijacks the functions of immune cells to promote viral spreading remains a challenge in the fight against infection. MΦ are ubiquitous tissue-resident cells, involved in tissue homeostasis and immunity. In HIV-1 infection, along with CD4+ T lymphocytes, MΦ serve as vectors for virus dissemination and as viral reservoirs, imp...
Godlee, Camilla Cerny, Ondrej Liu, Mei Blundell, Samkeliso Gallagher, Alanna E. Shahin, Meriam Holden, David W.
Published in
PLoS Pathogens
Salmonella enterica is an intracellular pathogen that causes a range of diseases from gastroenteritis to systemic typhoid fever. Its pathogenesis relies on virulence proteins known as effectors that are delivered into host cells and modulate host cellular processes. The ability of the Salmonella effector SteD to localise within host MHCII compartme...
Dempsey, Rachael Tamburrino, Giulia Schewe, Katarzyna E. Crowe, Jonathan Nuccitelli, Annalisa Dibben, Oliver
Published in
PLoS Pathogens
Vaccine effectiveness for the pandemic H1N1 component of the FluMist/Fluenz live attenuated influenza vaccine was lower than expected during the 2013–14 and 2015–16 influenza seasons in the USA. Previous studies highlighted the importance of vaccine viruses replicating sufficiently well in human cells that they could compete in quadrivalent formula...
Costa, Flavia G Horswill, Alexander R
Published in
PLoS pathogens
Skin health is influenced by the composition and integrity of the skin barrier. The healthy skin surface is an acidic, hypertonic, proteinaceous, and lipid-rich environment that microorganisms must adapt to for survival, and disruption of this environment can result in dysbiosis and increase risk for infectious diseases. This work provides a brief ...
Littlefield, Katherine M Watson, Renée O Schneider, Jennifer M Neff, Charles P Yamada, Eiko Zhang, Min Campbell, Thomas B Falta, Michael T Jolley, Sarah E Fontenot, Andrew P
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Published in
PLoS pathogens
As of January 2022, at least 60 million individuals are estimated to develop post-acute sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While elevated levels of SARS-CoV-2-specific T cells have been observed in non-specific PASC, little is known about their impact on pulmonary functio...
