Hiller, Bradley E. Yin, Yongjun Perng, Yi-Chieh de Araujo Castro, Ítalo Fox, Lindsey E. Locke, Marissa C. Monte, Kristen J. López, Carolina B. Ornitz, David M. Lenschow, Deborah J.
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Published in
PLoS Pathogens
Influenza viruses are respiratory viruses that cause significant morbidity and mortality worldwide. In the lungs, influenza A virus primarily infects epithelial cells that line the conducting airways and alveoli. Fibroblast growth factor-9 (FGF9) is a growth factor that has been shown to have antiviral activity and is upregulated during early IAV i...
Lindqvist, Birgitta Jütte, Bianca B. Love, Luca Assi, Wlaa Roux, Julie Sönnerborg, Anders Tezil, Tugsan Verdin, Eric Svensson, J. Peter
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PLoS Pathogens
Upon infection with HIV-1, viral DNA is integrated into the cellular genome and adopts the surrounding chromatin structure. Integrated viral DNA can lead to production of new viral particles, or remain latently integrated in the cell. The chromatin environment strongly influences this state. Moreover, the viral protein Tat plays an important role i...
Ward, Joseph C. Lasecka-Dykes, Lidia Neil, Chris Adeyemi, Oluwapelumi O. Gold, Sarah McLean-Pell, Niall Wright, Caroline Herod, Morgan R. Kealy, David Warner, Emma
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Published in
PLoS Pathogens
Foot-and-mouth disease (FMD) is a highly contagious viral disease posing a constant threat to the global livestock industry, as it remains endemic in many parts of the world. The development of novel control measures for FMD could have major economic and social value worldwide, however, this will require a deeper understanding of the molecular mech...
Prosser, Diann J. Chen, Jiani Ahlstrom, Christina A. Reeves, Andrew B. Poulson, Rebecca L. Sullivan, Jeffery D. McAuley, Daniel Callahan, Carl R. McGowan, Peter C. Bahl, Justin
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Published in
PLoS Pathogens
The recent first detection of highly pathogenic avian influenza (HPAI) virus in wild birds inhabiting the Atlantic Flyway of North America (Newfoundland, Canada in November 2021 and South Carolina, USA, in January 2022) raises concern for virus movement within this region. Here, we study IAV in wild waterfowl with focus on bird movements in combina...
Lu, Liaoxun Li, Tianhan Feng, Xinyu Liu, Zhilong Liu, Yang Chao, Tianzhu Gu, Yanrong Huang, Rong Zhang, Fanghui He, Le
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PLoS Pathogens
Chronic schistosome infection leads to exaggerated upregulation of PD-1 in the liver, and loss of PD-1 markedly increased T cell presence in the liver of schistosome infected mice, which was accompanied by suppressed Th2 cytokines but markedly increased IFN-γ secretion in CD4+ and CD8+ T cells. The beneficial T cell response did not result in eradi...
Klimova, Nela Holubova, Jana Streparola, Gaia Tomala, Jakub Brazdilova, Ludmila Stanek, Ondrej Bumba, Ladislav Sebo, Peter
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PLoS Pathogens
Of the three classical Bordetella species causing respiratory infections in mammals, only the human-specialized whooping cough agent B . pertussis produces the pertussis toxin (PT) as its major virulence factor. Human pertussis is an acute respiratory illness and the pleiotropic activities of pertussis toxin account for the characteristic systemic ...
Cao, Lili Luo, Yujie Guo, Xuefei Liu, Shengde Li, Siji Li, Junhong Zhang, Zeming Zhao, Yingchi Zhang, Qiao Gao, Feng
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PLoS Pathogens
Regulation of chromatin opening and gene expression underlies a key point during host defense against viral infection, which endows the host with timely and effective antiviral gene expression patterns. We previously reported that the nuclear matrix protein SAFA surveils viral RNA and regulates antiviral immune genes expression. However, how SAFA r...
Tamura, Tomokazu Torii, Shiho Kajiwara, Kentaro Anzai, Itsuki Fujioka, Yoichiro Noda, Kisho Taguwa, Shuhei Morioka, Yuhei Suzuki, Rigel Fauzyah, Yuzy
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Published in
PLoS Pathogens
It is difficult to characterize the function of NS1 in the post-genome replication stages in the virus life cycle of flaviviruses. Here, by means of protein-protein interaction network analyses and mutagenesis scanning, we identified a unique mutation in NS1 by which the protein loses its secretory capacity while retaining its genome replication ac...
Borbora, Salik Miskat Rajmani, Raju S. Balaji, Kithiganahalli Narayanaswamy
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PLoS Pathogens
Mycobacterium tuberculosis infection leads to the formation of lipid-laden cells (foamy macrophages-FMs) that offer a favorable shelter for its persistence. During infection, we observe a significant reduction in the expression of the E3 ubiquitin ligase, ITCH. This repression allows the sustenance of key lipid accretion molecules (ADRP and CD36), ...
Eyran, Tsuf Vaisman-Mentesh, Anna Taussig, David Dror, Yael Aizik, Ligal Kigel, Aya Rosenstein, Shai Bahar, Yael Ini, Dor Tur-Kaspa, Ran
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Published in
PLoS Pathogens
The fundamental idea guiding vaccine science is that an ideal vaccine should induce immunity similar to the immunity produced by natural infection. A vaccine is designed to “train” the immune system in a way that it will mimic the stimulation necessary for immune development, yet not produce active disease. Understanding the persistence of antibodi...
