Published in PLoS Pathogens
Piglets’ E . coli F18-induced diarrhea is one of the most common intestinal inflammatory diseases that leads to severe financial damages. However, the molecular mechanism underlying the resistance to E . coli F18 infection remains unclear. Here, FUT3-AS1 as a novel long non-coding RNA (lncRNA) was identified and could function as a positive regulat...
Published in PLoS Pathogens
Parasitic helminths (worms) infect people and animals throughout the world and are largely controlled with mass administration of anthelmintic drugs. There are a very limited number of anthelmintics available and parasitic helminths can rapidly develop resistance to these drugs. Ivermectin is a widely used anthelmintic in both humans and animals, b...
Published in PLoS Pathogens
As bacterial resistance to existing antibiotics increases and expands, scientists are exploring new approaches to combatting bacterial infections. There is a special need for antibiotics against Gram-negative bacteria, which are difficult to treat and can cause devastating infections. One underexplored possible antimicrobial target for Gram-negativ...
Published in PLoS Pathogens
Effective control of malaria is hampered by resistance to vector-targeted insecticides and parasite-targeted drugs. This situation is exacerbated by a critical lack of chemical diversity in both interventions and, as such, new interventions are urgently needed. Recent laboratory studies have shown that an alternative approach based on treating Anop...
Published in PLoS Pathogens
Whether growing harmlessly on our mucous membranes in competition with bacterial multitudes, or invading our tissues and bloodstream, the fungus Candida albicans must be capable of rapid growth when it finds abundant nutrients and favorable conditions. It must also be able to switch to stress- and survival mode when encountering host immune cells a...
Published in PLoS pathogens
The development of thermostable vaccines can relieve the bottleneck of existing vaccines caused by thermal instability and subsequent poor efficacy, which is one of the predominant reasons for the millions of deaths caused by vaccine-preventable diseases. Research into the mechanism of viral thermostability may provide strategies for developing the...
Published in PLoS pathogens
Published in PLoS pathogens
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone and non-histone proteins to form a minichromosome and utilizes posttranslational modifications (PTMs) "histone code" for its transcriptional regulation. HBV X protein (HBx) is known...
Published in PLoS pathogens
Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen displaying domain III (EDIII) of the POWV E glycoprotein. Immunization with POWV EDIII presented o...
Published in PLoS pathogens
Arboviruses are etiological agents of various severe human diseases that place a tremendous burden on global public health and the economy; compounding this issue is the fact that effective prophylactics and therapeutics are lacking for most arboviruses. Herein, we identified 2 bacterial lipases secreted by a Chromobacterium bacterium isolated from...
