Files, Daniel Clark Tacke, Frank O’Sullivan, Alexandra Dorr, Patrick Ferguson, William G. Powderly, William G.
Published in
PLoS Pathogens
This article reviews the literature examining the inflammatory pathways resulting in pulmonary and cardiovascular adverse events associated with the Coronavirus Disease 2019 (COVID-19) and their role in the disease process; it also reviews the mechanism of action and safety profile of cenicriviroc (CVC), a C-C chemokine receptor type 5 (CCR5) and C...
Hume, Adam J. Heiden, Baylee Olejnik, Judith Suder, Ellen L. Ross, Stephen Scoon, Whitney A. Bullitt, Esther Ericsson, Maria White, Mitchell R. Turcinovic, Jacquelyn
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Published in
PLoS Pathogens
Fittje, Pia Hœlzemer, Angelique Garcia-Beltran, Wilfredo F. Vollmers, Sarah Niehrs, Annika Hagemann, Kerri Martrus, Glòria Körner, Christian Kirchhoff, Frank Sauter, Daniel
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Published in
PLoS Pathogens
HIV infection remains a global health emergency that has caused around 36 million deaths. NK cells play an important role in the control of HIV-1 infections, and are able to detect and destroy infected cells using a large array of activating and inhibitory receptors, including KIRs. Here we demonstrate that CD155 serves as a functional interaction ...
Adisasmito, Wiku B Almuhairi, Salama Behravesh, Casey Barton Bilivogui, Pépé Bukachi, Salome A Casas, Natalia Cediel Becerra, Natalia Charron, Dominique F Chaudhary, Abhishek Ciacci Zanella, Janice R
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Published in
PLoS pathogens
Dasari, Vijayendra Beckett, Kirrilee Horsefield, Shane Ambalathingal, George Khanna, Rajiv
Published in
PLoS pathogens
There is now convincing evidence that the successful development of an effective CMV vaccine will require improved formulation and adjuvant selection that is capable of inducing both humoral and cellular immune responses. Here, we have designed a novel bivalent subunit vaccine formulation based on CMV-encoded oligomeric glycoprotein B (gB) and poly...
Figueiredo, Joana Henriques, Mafalda Xavier Catalão, Maria João Pinheiro, Sara Narciso, Ana Rita Mesquita, Francisco Saraiva, Bruno Manuel Carido, Madalena Cabanes, Didier Pinho, Mariana Gomes
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Published in
PLoS Pathogens
During their cell cycle, Gram-positive bacteria can be frequently found surrounded by a cellular envelope, which includes glycopolymers such as peptidoglycan, wall teichoic acids or capsular polysaccharides, whose composition is adjusted to the external insults they may find. The clarification of how bacteria tune synthesis of these three macromole...
Heath, Joseph R Dembowski, Jill A
Published in
PLoS pathogens
Saso, Wakana Yamasaki, Masako Nakakita, Shin-ichi Fukushi, Shuetsu Tsuchimoto, Kana Watanabe, Noriyuki Sriwilaijaroen, Nongluk Kanie, Osamu Muramatsu, Masamichi Takahashi, Yoshimasa
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Published in
PLoS Pathogens
SARS-CoV-2, which has been highly transmissible and rapidly spreading worldwide, has caused approximately 458 million confirmed cases of COVID-19 with more than 6 million deaths by March 2022. Here we found that SARS-CoV-2 infection was significantly inhibited by α2-6-linked sialic acid-containing compounds and by depletion of cell surface sialic a...
Ma, Henry Albe, Joseph R. Gilliland, Theron McMillen, Cynthia M. Gardner, Christina L. Boyles, Devin A. Cottle, Emily L. Dunn, Matthew D. Lundy, Jeneveve D. Salama, Noah
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Published in
PLoS Pathogens
Although naturally transmitted by mosquito, Venezuelan equine encephalitis viruses (VEEV) can be highly infectious when aerosolized. In humans, VEEV are only rarely fatal but cause a severe, biphasic fever with neurological symptoms including severe headache, a stiff neck, and photophobia. We report here our efforts to further characterize the dise...
Smith, Daniel F Q Casadevall, Arturo
Published in
PLoS pathogens
Pathogenic Potential (PP) is a mathematical description of an individual microbe, virus, or parasite's ability to cause disease in a host, given the variables of inoculum, signs of disease, mortality, and in some instances, median survival time of the host. We investigated the relationship between pathogenic potential (PP) and infective inoculum (I...
