A Field Trip to the Mesozoic
Published in PLoS Biology
Henry Gee and Luis Rey have provided an entertaining and creative account of the life and times of dinosaurs
Patricia Goldman-Rakic
Published in PLoS Biology
L’avenir hypertextuel des Annales
Published in Annales Pharmaceutiques Francaises
Comparative Genomics
Published in PLoS Biology
Comparing the genomes of two different species allow the exploration of a host of intriguing evolutionary and genetic questions
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome.
Published in PLoS biology
The JAMM (JAB1/MPN/Mov34 metalloenzyme) motif in Rpn11 and Csn5 underlies isopeptidase activities intrinsic to the proteasome and signalosome, respectively. We show here that the archaebacterial protein AfJAMM possesses the key features of a zinc metalloprotease, yet with a distinct fold. The histidine and aspartic acid of the conserved EX(n)HS/THX...
Research advocacy: why every scientist should participate.
Published in PLoS biology
Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.
Published in PLoS biology
In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration through the posterior midgut (PMG) is the first active step during Drosophila germ cell migration. Here we report the identification of a novel G protein-co...
How mammals acquire and distribute iron needed for oxygen-based metabolism.
Published in PLoS biology
Antigen-specific T cells: analyses of the needles in the haystack.
Published in PLoS biology
Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification....
Published in PLoS biology
Heritable, but reversible, changes in transposable element activity were first observed in maize by Barbara McClintock in the 1950s. More recently, transposon silencing has been associated with DNA methylation, histone H3 lysine-9 methylation (H3mK9), and RNA interference (RNAi). Using a genetic approach, we have investigated the role of these modi...
