Genomics research and malaria control: great expectations.
Published in PLoS biology
Analysis of sensitivity and rapid hybridization of a multiplexed Microbial Detection Microarray
Published in Journal of Virological Methods
Microarrays have proven to be useful in rapid detection of many viruses and bacteria. Pathogen detection microarrays have been used to diagnose viral and bacterial infections in clinical samples and to evaluate the safety of biological drug materials. A multiplexed version of the Lawrence Livermore Microbial Detection Array (LLMDA) was developed an...
Molecular phylogeography of Culex quinquefasciatus mosquitoes in central Bangladesh
Published in Acta Tropica
Mosquitoes in the Culex pipiens complex are a major vector of numerous parasitic and arboviral diseases. Here we report the phylogeography of a prevalent Culex mosquito, Cx. quinquefasciatus, from three locations in Bangladesh: Dhaka, Savar and Mymensingh. Sequence analysis of the genes encoding mitochondrial cytochrome oxidase subunit II, nuclear ...
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5...
Published in PLoS biology
The cellular pathways involved in maintaining genome stability halt cell cycle progression in the presence of DNA damage or incomplete replication. Proteins required for this pathway include Rad17, Rad9, Hus1, Rad1, and Rfc-2, Rfc-3, Rfc-4, and Rfc-5. The heteropentamer replication factor C (RFC) loads during DNA replication the homotrimer prolifer...
Tough mining: the challenges of searching the scientific literature.
Published in PLoS biology
Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development.
Published in PLoS biology
The platelet-derived growth factor beta receptor (PDGFRbeta) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many years. We have sought to determine the role of individual signaling components downstream of this receptor in vivo by analyzing an allelic series of ...
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.
...Published in PLoS biology
The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a common ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. They have the same chromosome number and genome sizes, and they occupy the same ecological niche. To explore the basis for this striking conservation of structure and functi...
Linkage of osteoporosis to chromosome 20p12 and association to BMP2.
...Published in PLoS biology
Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations. Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have significant genetic components that are largely unknown. Linkage analysis in a large number of extended osteoporosis families in Iceland, using a phenotype that combines os...
GAD2 on chromosome 10p12 is a candidate gene for human obesity.
...Published in PLoS biology
The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus...
Biodiversity Conservation Demands Open Access
Published in PLoS Biology
Open access is vital to the progress of scientific thought and advancement of many disciplines, but particularly so for conservation science
