Published in PLoS Biology
What is replication? This Perspective article proposes that the answer shifts the conception of replication from a boring, uncreative, housekeeping activity to an exciting, generative, vital contributor to research progress.
Published in PLoS Biology
Pre-registration and registered reports of research that develops theories and hypotheses has the potential to reduce waste and increase the value of biomedical research. This Perspective argues that journals and scientists should develop and experiment with pre-registration formats for discovery research.
Published in PLoS Biology
This Perspective article introduces the concept of "frontloaded" selectivity as a means for journals to remain highly discerning while also eliminating publication bias. The newly launched "Preregistered Research Article" format at PLOS Biology (AKA Registered Reports) is a working example of this principle.
Published in PLoS Biology
This Unsolved Mystery article considers the paradoxical case of TLR7 and TLR8, two apparently "suicidal" genes recently reported as controlling offspring sex ratio. How can it be possible for X-linked genes to selectively inhibit the success of X-bearing sperm, without immediately being eliminated by natural selection?
Published in PLoS Biology
A study of gnotobiotic fruit flies shows that the animal is involved in an integrated nutritional network with its facultative commensal bacteria, centered around the utilization and sharing of nutrients.
Published in PLoS biology
[This corrects the article DOI: 10.1371/journal.pbio.3000572.].
Published in PLoS biology
[This corrects the article DOI: 10.1371/journal.pbio.3000464.].
Published in PLoS Biology
The endocrine signals governing the homeostatic regulation of body weight are incompletely mapped; this Unsolved Mystery article discusses the mounting evidence that points to the existence of unidentified hormonal factors protecting against excessive weight gain.
Published in PLoS biology
Ex situ seed banking was first conceptualized and implemented in the early 20th century to maintain and protect crop lines. Today, ex situ seed banking is important for the preservation of heirloom strains, biodiversity conservation and ecosystem restoration, and diverse research applications. However, these efforts primarily target microalgae and ...
Published in PLoS Biology
This Community Page article describes an ongoing large-scale structured initiative at the Berlin Institute of Health which aims at improving the robustness, reproducibility and transparency of research in an academic biomedical setting.
