Paradoxes of Difference
Published in PLoS Biology
A new play tackles the politics around race and gender in science
Hormonal regulation of plant growth and development.
Published in PLoS biology
What is life--and how do we search for it in other worlds?
Published in PLoS biology
The genome Assembly Archive: a new public resource.
Published in PLoS biology
Bridging psychology and mathematics: can the brain understand the brain?
Published in PLoS biology
The conservation business.
Published in PLoS biology
Continued colonization of the human genome by mitochondrial DNA.
Published in PLoS biology
Integration of mitochondrial DNA fragments into nuclear chromosomes (giving rise to nuclear DNA sequences of mitochondrial origin, or NUMTs) is an ongoing process that shapes nuclear genomes. In yeast this process depends on double-strand-break repair. Since NUMTs lack amplification and specific integration mechanisms, they represent the prototype ...
Conflict over male parentage in social insects.
Published in PLoS biology
Mutual policing is an important mechanism that maintains social harmony in group-living organisms by suppressing the selfish behavior of individuals. In social insects, workers police one another (worker-policing) by preventing individual workers from laying eggs that would otherwise develop into males. Within the framework of Hamilton's rule there...
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.
Published in PLoS biology
Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense against retroviral infection involves a single-stranded DNA-editing enzyme, APOBEC3G, that causes hypermutation of HIV. The HIV-encoded virion infectivity factor (Vif) protein targets APOBEC3G for ...
Sir2-independent life span extension by calorie restriction in yeast.
Published in PLoS biology
Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with calorie restriction. Deletion...
