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Twenty steps to ingrain power asymmetry in global health biomedical research

Published in PLoS Biology

Health research in low‐income settings must prioritize sustainability in order to truly impact target diseases in the long term; this Perspective article satirically summarizes how biomedical investigators from high-income countries can collaboratively work to (not) accomplish this.

Identifying and prioritizing potential human-infecting viruses from their genome sequences

Published in PLoS Biology

Powered by metagenomics, viral discovery is outpacing our capacity for the downstream characterization needed to fully assess zoonotic potential. This Primer explores the implications of a PLOS Biology study which uses machine learning to prioritize novel viruses based on genomic signatures alone.

Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation

Published in PLoS Biology

Memory performance plays a crucial role across the human life span, from early education to age-related decline. This Primer explores the implications of a new study in PLOS Biology which shows that verbal learning can be enhanced by applying repetitive transcranial magnetic stimulation over the left prefrontal cortex.

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

Published in PLoS Biology

For successful colonization, parasites need to target the plant immune system. This Primer explores a new study in PLOS Biology which reveal that unrelated parasites have evolved effectors which specifically suppress the function of helper NLRs, explaining the complex plant-parasite coevolutionary dynamics.

Synthesis of human amyloid restricted to liver results in an Alzheimer’s disease-like neurodegenerative phenotype

Published in PLoS Biology

Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the liver can promote brain pathology, supporting that peripheral Aβ can contribute to neurodegeneration.

Expansion microscopy provides new insights into the cytoskeleton of malaria parasites including the conservation of a co...

Published in PLoS Biology

A 3-year evaluation of preclinicaltrials.eu reveals room for improvement in preregistration of animal studies

Published in PLoS Biology

This Community Page article presents a 3-year evaluation of the first platform dedicated to preregistration of animal studies, www.preclinicaltrials.eu , and comparable platforms, encouraging the scientific community to embrace preregistration in a move towards more effective animal research.

The ‘antiviral state’ has shaped the CpG composition of the vertebrate interferome to avoid self-targeting

Published in PLoS Biology

Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.

Why Lyme disease is common in the northern US, but rare in the south: The roles of host choice, host-seeking behavior, a...

Published in PLoS Biology

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

Published in PLoS Biology

In this issue of PLOS Biology , Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apopt...