Yu, Jialu
Published in
Open Medicine
Background Neural cell damage is an important cause of exacerbation of depression symptoms caused by hypoxia, but the mechanism behind it is still unclear. The purpose of this study is to elucidate the role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)/mitofusin-2 (MFN2) signaling axis in the development of depress...
He, Quan Xu, Shuanglan Ma, Xiaomei Qian, Yuanxia Lu, Xuzhi Feng, Weiqi Chen, Zi
Published in
Open Medicine
Src-homology region 2 domain-containing phosphatase 1 (SHP-1) is considered an anti-inflammatory factor, but its role in chronic obstructive pulmonary disease (COPD) remains unknown. Herein, overexpression of SHP-1 was utilized to explore the functions of SHP-1 in COPD models established by stimulating 16HBE cells with cigarette smoke extracts (CSE...
Hu, Yun Zhou, Ting Li, Qingye
Published in
Open Medicine
Objective In this prospective observational study, we aimed to investigate the serum levels of sirtuin (SIRT)3 in epilepsy patients and its association with the severity of the disease. Methods This prospective observational study included 203 patients with symptomatic epilepsy and 100 healthy controls who visited our hospital from November 2019 to...
Qiu, Lingbing Ma, Tianyi Guo, Yunmiao Chen, Jugao
Published in
Open Medicine
Objective This study aims to address the substantive issue of lacking reliable prognostic biomarkers in hepatocellular carcinoma (HCC) by investigating the relationship between TP53-inducible glycolysis and apoptosis regulator (TIGAR) and HCC prognosis using The Cancer Genome Atlas database. Methods (1) Integrated statistical analyses, including lo...
Gan, Xin Chen, Xin Zeng, Yunqian Li, Mengwei Nie, Mingbo Kang, Hao
Published in
Open Medicine
Background The anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) are important structures to maintain knee stability. The present study aimed to further enrich understandings of the morphology of the cruciate ligaments and explore the relationship between the diameter of ACL and PCL. Method This study collected valid MRI sample...
Saridas, Ali Vural, Nafis Duyan, Murat Guven, Hasan Can Ertas, Elif Cander, Basar
Published in
Open Medicine
Introduction Acute appendicitis (AA) is the predominant condition responsible for acute abdominal pain across all age demographics. The purpose of this research is to determine if the hemoglobin, albumin, lymphocyte, and platelet (HALP) and modified HALP (m-HALP) scores differ between complicated and uncomplicated appendicitis in patients diagnosed...
Rančić, Aleksandar Milosavljević, Miloš N. Rosić, Nikola Milovanović, Dragan Folić, Marko Zečević, Dejana Ružić Petrović, Nemanja Čorbić, Mirjana Milojević Dabanović, Vera Janković, Slobodan M.
...
Published in
Open Medicine
Objective The pharmacokinetics of meropenem are significantly altered in critically ill patients. A population pharmacokinetic study was designed to estimate typical values of meropenem clearance in critically ill patients and evaluate potential factors of influence. Methods After meropenem reached a steady state in each patient, two blood samples ...
Nicolosi, Giada Donzella, Martina Polizzi, Alessandro Angjelova, Angela Santonocito, Simona Zanoli, Luca Annunziata, Marco Isola, Gaetano
Published in
Open Medicine
Objectives This narrative review aims to update the current evidence and offer insight into the new non-invasive ultrasound techniques used to early identify degenerative vascular changes in subjects with periodontitis and to investigate if these methodologies could be useful to identify subclinical cardiovascular disease (CVD) dysfunction in perio...
Zhou, Jie Xu, Yixin Wang, Haitao Liu, Zhilin
Published in
Open Medicine
Background No intervention definitively extends transplant-free survival in primary sclerosing cholangitis (PSC). Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), may enhance PSC prognosis, but their efficacy is debated. Methods We analyzed HMGCR single-nucleotide polymorphisms from published genome-wide association s...
Guo, Yingbo Gao, Wenfeng Ding, Xinyu Cai, Qian Bai, Yu
Published in
Open Medicine
To investigate the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals in the treatment of renal fibrosis (RF). We searched articles from databases (PubMed, Embase, The Cochrane Library, CNKI, and Wanfang data) and references of included studies. The quality of literature was evaluated...
