Zhang, Bo Liu, Yuan Zhang, Jiangnan
Published in
Oncology letters
MicroRNAs (miRNAs/miRs) are small non-coding RNAs, which serve important roles in tumor progression. The present study analyzed the role of miR-19a-3p in the chemosensitivity of osteosarcoma (OS) cells. Overexpression of miR-19a-3p was observed in OS cells and a cisplatin-resistant MG63 cell line was subsequently constructed. It was observed that m...
Zhang, Ying Lin, Xin-Yu Zhang, Jiao-Hui Xie, Zheng-Lu Deng, Hui Huang, Yi-Fang Huang, Xiao-Hong
Published in
Oncology letters
Resistance to apoptosis is a characteristic of cancer. Curcumin has become a potential anticancer drug for its pro-apoptotic effects, but the underlying mechanisms remain unclear. Furthermore, the Notch3-p53 signaling axis serves an important role in cell fate. The present study was designed to investigate the antitumor effect of curcumin by the No...
Li, Mengge Zhao, Yalin Liu, Xiaoli Dang, Zhibo Wang, Xinhui Jiang, Yuyong Yang, Zhiyun
Published in
Oncology letters
The development of minimally invasive treatment over the last two decades has had a great impact on hepatitis B virus (HBV)-associated primary liver cancer. The model for end-stage liver disease (MELD) score is the optimal evaluated parameter for mortality in patients with end-stage liver disease. However, the association between MELD score and min...
Pan, Qiaohong Ji, Jianwu
Published in
Oncology letters
Diagnostic value of ultrasound (US) and magnetic resonance imaging (MRI) in breast cancer were investigated. One hundred and forty breast cancer patients diagnosed in Heping Hospital Affiliated to Changzhi Medical College from June 2016 to June 2018 were collected, used as breast cancer group, 80 patients with benign breast tumor in the same period...
Zhou, Haibo Yang, Li Xu, Xinhua Lu, Mingqian Guo, Rong Li, Daojun Huang, Qiao Liu, Yang Deng, Glenn Xu, Yalin
...
Published in
Oncology letters
Downregulation of microRNA-34a (miR-34a) has frequently been observed in esophageal squamous cell carcinoma (ESCC). However, the underlying role and molecular mechanism of miR-34a in ESCC remains largely unknown. In the current study, it was demonstrated that miR-34a was downregulated and forkhead box M1 (FOXM1), a target gene of miR-34a, was upreg...
Peng, Qiliang Lin, Kaisu Shen, Yi Zhou, Ping Fan, Shaonan Shen, Yuntian Zhu, Yaqun
Published in
Oncology letters
Currently, neoadjuvant chemoradiotherapy (CRT) followed by radical surgery is the standard of care for locally advanced rectal cancer. However, to the best of our knowledge, there are no effective biomarkers for predicting patients who may benefit from neoadjuvant treatment. The aim of the current study was to screen potential crucial genes and pat...
Hou, Yi
Published in
Oncology letters
MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell proliferation, migration and invas...
Gao, Xiang Liu, Zhenping Zhong, Meifeng Wu, Kunhe Zhang, Yuzhao Wang, Hongmei Zeng, Tao
Published in
Oncology letters
Effective therapy for breast cancer has been extensively studied worldwide, particularly for triple-negative breast cancer and drug-resistant subtypes. DNA/RNA-binding protein KIN17 (kin17) has been reported to be significantly upregulated in breast cancer cells, and is proposed to serve a role in the regulation of cell proliferation. The present s...
Li, Li Feng, Ru Fei, Sujuan Cao, Jiang Zhu, Qinqin Ji, Guozhong Zhou, Jianwei
Published in
Oncology letters
NANOGP8 is one of the NANOG pseudogenes and is expressed together with NANOG in multiple tumor tissues and cell lines. The biological functions of NANOGP8 in progression of gastric cancer are unclear. In the present study, the role of NANOGP8 was investigated in gastric cancer cells. The gathered data demonstrated that NANOG expression in both mRNA...
Wang, Wei Shen, Huiliang Cao, Guanglei Huang, Jiang
Published in
Oncology letters
Increasing evidence indicates that long non-coding RNA (lncRNA) is involved in a number of types of human cancer and functions as an oncogene or tumor suppressor. However, little is known about the role of lncRNA X-inactive specific transcript (XIST) in osteosarcoma. In the present study, the expression of lncRNA XIST was analyzed in 56 osteosarcom...
