Qiu, Jing Zhao, Juan Zuo, Anjun Liu, Lan Liu, Qiaoqiao Pan, Huazheng Yuan, Xiao
Published in
Oncology letters
Oral squamous cell carcinoma (OSCC) is one of the most fatal types of oral cancer worldwide. Forkhead box M1 (FOXM1) is associated with the occurrence and development of a number of types of human cancer, but its function in OSCC remains unclear. The present study aimed to explore the effect of FOXM1 downregulation using lentivirus-mediated short h...
Son, Dasom Kong, Hyun-Kyung Kim, Yesol Song, Min-Ji Kim, Hyong Pyo Lee, Han Woong Park, Jong Hoon
Published in
Oncology letters
Lymphocyte antigen 6 family member K (LY6K) is upregulated in a number of types of cancer and promotes tumor cell proliferation and metastasis. In addition, LY6K is involved in tamoxifen resistance in breast cancer. However, the in vivo molecular mechanism of LY6K has not yet been investigated. In the present study, transgenic mice overexpressing h...
Xiao, Baoqiang Shi, Xuejing Bai, Jianping
Published in
Oncology letters
The present study aims to investigate the effect of miR-30a on the proliferative and invasive abilities of breast cancer cells, and to observe the role of miR-30a in the pathogenesis of breast cancer. With the increase of pathological grade and malignant degree of breast cancer cells, the miR-30a expression level gradually decreased (P
Çetin, İdil Topçul, Mehmet R
Published in
Oncology letters
In the present study, the in vitro cytotoxic effect of a novel transforming growth factor-β receptor inhibitor, LY2109761, was investigated in the human cervix carcinoma HeLa cell lines. For the purpose of the present study, cell index values obtained using the xCELLigence Real-Time Cell Analysis DP instrument, and mitotic, labelling and apoptotic ...
Li, Yuankun Liu, Cuihua Liao, Yumei Wang, Wuliang Hu, Bin Lu, Xiaoqin Cui, Jinquan
Published in
Oncology letters
In the present study, differentially expressed microRNAs (miRNAs) in peritoneal exosomes that were isolated from 10 patients with epithelial ovarian cancer (EOC) with metastasis in the abdominal cavity and 10 participants without cancer (NC) were identified. These differentially expressed miRNAs that were revealed by next-generation sequencing were...
Zhu, Huiping Ge, Xiaolin Lu, Yufeng Zuo, Yun Qin, Qin Sun, Xinchen Yang, Min
Published in
Oncology letters
Concurrent chemoradiotherapy (CCRT) is an effective first-line treatment for esophageal squamous cell carcinoma (ESCC). The present study aimed to compare clinical outcomes between three nedaplatin-based regimens for CCRT of ESCC. Patients with stage II-III thoracic ESCC in China between January 2012 and May 2016 were included. Patients received es...
Kim, Su Mi Kim, Yun Oh Lee, Min Kyoung Chung, Youn Jee Jeung, In Cheul Kim, Mee Ran Kim, Jang Heub
Published in
Oncology letters
Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) is a regulator of the female reproductive system, an indicator of ovarian reserve and a growth inhibitor of Müllerian duct-derived tumors in vivo and in vitro. The objective of the present study was to analyze MIS/AMH type II receptor (MIS/AMHRII) protein and mRNA expression in healthy...
Valdatta, Luigi Perletti, Gianpaolo Maggiulli, Francesca Tamborini, Federico Pellegatta, Igor Cherubino, Mario
Published in
Oncology letters
The aim of the present study was to determine the association between preoperative frailty and the onset of surgical complications in patients diagnosed with massive non-melanoma skin cancer subjected to plastic and reconstructive surgery. A retrospective analysis was performed on a cohort of 587 patients with non-melanoma skin cancer, selected on ...
Tian, Linglin Li, Yuan Chang, Ruqi Zhang, Peng Zhang, Jian Huo, Lijuan
Published in
Oncology letters
Colorectal cancer caused by inflammatory bowel disease is referred as colitis-associated cancer (CAC). The mechanism underling CAC is not fully understood. In the present study, the role of interleukin-9 (IL-9) in CAC was examined. The current study included 12 colorectal tissue specimens and matched adjacent tissues from CAC. The expression of IL-...
Zhao, Hong Zhuang, Yafei Li, Ruibin Liu, Yinyin Mei, Zijie He, Zhongshi Zhou, Fuxiang Zhou, Yunfeng
Published in
Oncology letters
The present study examined the radiation biological response of cancer cells to different fractional irradiation doses and investigates the optimal fractional irradiation dose with improved biological effects. Radiobiological studies were performed at the molecular and cellular levels to provide insights into DNA damage and repair, and the apoptosi...
