Meng, Mingming Liu, Sanhong Wang, Chen Gu, Xinjin Linghu, Enqiang Xue, Xinying
Published in
Oncology Letters
Pancreatic cancer is one of the most life-threatening malignancies worldwide. Despite advances in checkpoint immunotherapy for patients with cancer, the current immunotherapies have demonstrated limited benefits for the treatment of pancreatic cancer. Apart from the intricate microenvironments that restrict T-cell function, membrane proteins other ...
Bu, Lijia Wang, Rong Liu, Pingping Da, Jie
Published in
Oncology Letters
The biological roles of the newly identified long non-coding RNA family with sequence similarity 83 member H antisense 1 (FAM83H-AS1) in esophageal squamous cell carcinoma (ESCC) have remained largely elusive. In the present study, it was determined that, in comparison with paired para-tumorous tissues or normal esophageal epithelial cells, FAM83H-...
Kamikawa, Yohei Yokota, Kento Oikawa, Kosuke Sato, Fuyuki Muragaki, Yasuteru
Published in
Oncology Letters
Myxoid liposarcoma (MLS) is thought to occur due to defective adipocytic differentiation in mesenchymal stem cells. A promising strategy for MLS treatment is the prevention of sarcomagenesis by promoting the terminal differentiation of MLS cells into adipocytes. Previous studies have reported that the suppression of megakaryoblastic leukemia 1 (MKL...
Yi, Xiuling Liu, Chunlei
Published in
Oncology Letters
Osteosarcoma (OS) is a type of primary bone tumor, which is one of the leading causes of cancer-related death. MicroRNA (miR)-605 has been demonstrated to act as a prognostic biomarker and therapeutic target in various cancers, such as breast cancer and non-small cell lung cancer, but its function in OS remains unclear. The aim of the present study...
Li, Jiarui Chen, Junxin Hu, Zhijun Xu, Wenbin
Published in
Oncology Letters
Osteosarcoma (OS) is a common bone tumor with high mortality worldwide. The long-term survival rate of patients with metastatic or recurrent disease is
Li, Tingting Jia, Lei Deng, Yu Wang, Bo Quan, Song
Published in
Oncology Letters
Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these dat...
Yan, Shibai Fang, Juntao Zhu, Yuanqiang Xie, Yong Fang, Feng
Published in
Oncology Letters
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a specific tumor immune microenvironment (TIME). Therefore, investigating prognostic immune-related genes (IRGs) that are closely associated with TIME to predict PDAC clinical outcomes is necessary. In the present study, 459 samples of PDAC from the Genotype-Tissue Expression databas...
Zhu, Xuan Li, Tao Niu, Xing Chen, Lijie Ge, Chunlin
Published in
Oncology Letters
Ju, Lixia Dong, Zhiyi Yang, Juan Li, Minghua
Published in
Oncology Letters
Although targeted therapy has achieved a great breakthrough in the treatment of lung adenocarcinoma, there are still no effective targeted drugs for lung squamous cell carcinoma (SqCC). In addition, as immunotherapy can only prolong the overall survival (OS) of lung SqCC by ≤5 months, chemotherapy and radiotherapy are still the main types of therap...
Zhao, Yi-Bin Yang, Shao-Hui Shen, Jie Deng, Ke Li, Qi Wang, Yu Cui, Wei Ye, Hua
Published in
Oncology Letters
Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, the tumor tissues of 40 patients...
