Wang, Ying-Nan Ruan, Dan-Yun Wang, Zi-Xian Yu, Kai Rong, Dai-Lin Liu, Ze-Xian Wang, Feng Hu, Jia-Jia Jin, Ying Wu, Qi-Nian
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Published in
Oncogene
Dysregulated cholesterol metabolism is a hallmark of colorectal cancer (CRC). However, the usage of cholesterol-lowering agents seemed to have no benefit in CRC patients. In this study, we focused on the cholesterol-nuclear receptors (NRs) axis as a strategy. Cholesterol and its derivatives work as ligands for different nuclear receptors, thus prom...
Chen, Han Chen, Xuhong Zhang, Zhuojun Bao, Wenhao Gao, Zhiqing Li, Difeng Xie, Xiaoyi Zhou, Ping Yang, Chunxiao Zhou, Zhongqiu
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Published in
Oncogene
Glioma is the most common malignant primary brain tumor with aggressiveness and poor prognosis. Although extracellular vesicles (EVs)-based cell-to-cell communication mediates glioma progression, the key molecular mediators of this process are still not fully understood. Herein, we elucidated an EVs-mediated transfer of suprabasin (SBSN), leading t...
Cartón-García, Fernando Brotons, Bruno Anguita, Estefanía Dopeso, Higinio Tarragona, Jordi Nieto, Rocio García-Vidal, Elia Macaya, Irati Zagyva, Zsuzsanna Dalmau, Mariona
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Published in
Oncogene
Colorectal cancer causes >900,000 deaths every year and a deeper understanding of the molecular mechanisms underlying this disease will contribute to improve its clinical management and survival. Myosin Vb (MYO5B) regulates intracellular vesicle trafficking, and inactivation of this myosin disrupts the polarization and differentiation of intestinal...
Chand, Vaibhav Liao, Xiubei Guzman, Grace Benevolenskaya, Elizaveta Raychaudhuri, Pradip
Published in
Oncogene
Xu, Chunjie Gu, Lei Kuerbanjiang, Manzila Jiang, Chunhui Hu, Lipeng Liu, Ye Xue, Hanbing Li, Jun Zhang, Zhigang Xu, Qing
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Published in
Oncogene
The microenvironment of distant organ plays vital roles in regulating tumor metastases. However, little is known about the crosstalk between metastasized tumor cells and target organs. Herein, we found that EFNB2 expression was upregulated in liver metastases (LM) of colorectal cancer (CRC), but not in pulmonary metastases (PM) or primary CRC tumor...
Coetzee, Abigail S Carter, Edward P Rodríguez-Fernández, Lucía Heward, James Wang, Qiaoying Karim, Saadia A Boughetane, Lina Milton, Christopher Uyulur, Firat Morton, Jennifer P
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Published in
Oncogene
Pancreatic stellate cells (PSCs) are key to the treatment-refractory desmoplastic phenotype of pancreatic ductal adenocarcinoma (PDAC) and have received considerable attention as a stromal target for cancer therapy. This approach demands detailed understanding of their pro- and anti-tumourigenic effects. Interrogating PSC-cancer cell interactions i...
Cui, Kaisa Gong, Liang Zhang, Han Chen, Ying Liu, Bingxin Gong, Zhicheng Li, Jiuming Wang, Yuanben Sun, Shengbai Li, Yajun
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Published in
Oncogene
Extensive protein synthesis is necessary for uncontrolled cancer cell proliferation, requiring hyperactive ribosome biogenesis. Our previous Pan-cancer study has identified EXOSC8 as a potential copy number variation (CNV)-driven rRNA metabolism-related oncogene in colorectal cancer (CRC). Herein, we further investigated proliferation-prompting fun...
Tsang, Susan V Rainusso, Nino Liu, Meng Nomura, Motonari Patel, Tajhal D Nakahata, Kengo Kim, Ha Ram Huang, Shixia Rajapakshe, Kimal Coarfa, Cristian
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Published in
Oncogene
Osteosarcoma, the most common pediatric bone tumor, is an aggressive heterogeneous malignancy defined by complex chromosomal aberrations. Overall survival rates remain at ~70%, but patients with chemoresistant or metastatic disease have extremely poor outcomes of
Sun, Si-Jia Ai, Ying-Jie Duan, Kun-Long Zhang, Jin-Ye Zhang, Cheng Sun, Yi-Ping Xiong, Yue Guan, Kun-Liang Yuan, Hai-Xin
Published in
Oncogene
TET2 (ten-eleven-translocation) protein is a Fe(II)- and α-ketoglutarate-dependent dioxygenase that catalyzes DNA demethylation to regulate gene expression. While TET2 gene is frequently mutated in hematological cancer, its enzymatic activity is also compromised in various solid tumors. Whether TET2 deficiency creates vulnerability for cancer cells...
Stubbs, Felicity E Flynn, Benjamin P Rivers, Caroline A Birnie, Matthew T Herman, Andrew Swinstead, Erin E Baek, Songjoon Fang, Hai Temple, Jillian Carroll, Jason S
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Published in
Oncogene
ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been putatively linked to glucocorticoid resistance. Here, we interrogate the impact of siRNA knockdown of ARID1a compared to a functional interference approach in the HeLa human cervical cancer c...
