Yu, Zeyuan Jiang, Xiangyan Qin, Long Deng, Haixiao Wang, Jianli Ren, Wen Li, Hongbin Zhao, Lei Liu, Huanxiang Yan, Hong
...
Published in
Oncogene
Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficiently efficacious for GC. Thus, we screened new pot...
Periyasamy, Manikandan Singh, Anup K Gemma, Carolina Farzan, Raed Allsopp, Rebecca C Shaw, Jacqueline A Charmsaz, Sara Young, Leonie S Cunnea, Paula Coombes, R Charles
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Published in
Oncogene
The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels, and consequently limiting cancer mutagenesis. We...
Poorebrahim, Mansour Melief, Jeroen Pico de Coaña, Yago L Wickström, Stina Cid-Arregui, Angel Kiessling, Rolf
Published in
Oncogene
In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Exhaustion and senescence are two critical dysfuncti...
Lu, Jun Bang, Heejin Kim, Su Mi Cho, Soo-Jeong Ashktorab, Hassan Smoot, Duane T Zheng, Chao-Hui Ryeom, Sandra W Yoon, Sam S Yoon, Changhwan
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Published in
Oncogene
The poor prognosis of gastric cancer (GC) results largely from metastasis and chemotherapy resistance. Toward novel therapeutic strategies that target or evade these phenomena, we evaluated the function of the transcriptional regulator transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) in GC cells, including stem-like cells. In this study, the cor...
Han, Chuanhui Zhang, Anli Liu, Zhida Moore, Casey Fu, Yang-Xin
Published in
Oncogene
Recently, immune checkpoint blockade (ICB), especially anti-programmed death 1 (anti-PD-1) and anti-programmed death-ligand 1 (anti-PD-L1) therapy, has become an increasingly appealing therapeutic strategy for cancer patients. However, only a small portion of patients responds to anti-PD treatment. Therefore, treatment strategies are urgently neede...
Cui, Chunhong Liu, Yi Gerloff, Dennis Rohde, Christian Pauli, Cornelius Köhn, Marcel Misiak, Danny Oellerich, Thomas Schwartz, Schraga Schmidt, Lars-Henning
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Published in
Oncogene
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide underlining the urgent need for new biomarkers and therapeutic targets for this disease. Long noncoding RNAs are critical players in NSCLC but the role of small RNA species is not well understood. In the present study, we investigated the role of H/ACA box small nucle...
Kaushik, Garima Seshacharyulu, Parthasarathy Rauth, Sanchita Nallasamy, Palanisamy Rachagani, Satyanarayana Nimmakayala, Rama Krishna Vengoji, Raghupathy Mallya, Kavita Chirravuri-Venkata, Ramakanth Singh, Amar B
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Published in
Oncogene
Pancreatic cancer (PC) is difficult to defeat due to mechanism (s) driving metastasis and drug resistance. Cancer stemness is a major challenging phenomenon associated with PC metastasis and limiting therapy efficacy. In this study, we evaluated the pre-clinical and clinical significance of eradicating pancreatic cancer stem cells (PCSC) and its co...
Tan, Xiuxiang Sivakumar, Shivan Bednarsch, Jan Wiltberger, Georg Kather, Jakob Nikolas Niehues, Jan de Vos-Geelen, Judith Valkenburg-van Iersel, Liselot Kintsler, Svetlana Roeth, Anjali
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Published in
Oncogene
Pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) are both deadly cancers and they share many biological features besides their close anatomical location. One of the main histological features is neurotropism, which results in frequent perineural invasion. The underlying mechanism of cancer cells favoring growth by and through th...
He, Qin Lin, Zhuoying Wang, Zhihui Huang, Wenjie Tian, Dean Liu, Mei Xia, Limin
Published in
Oncogene
Metastasis is the main reason for high mortality in hepatocellular carcinoma (HCC) patients and the molecular mechanism remains unclear. Therefore, it is important to elucidate the mechanism underlying HCC metastasis. Here, we report a novel role of SIX homeobox 4 (SIX4), one of the SIX gene family, in promoting HCC metastasis. The elevated express...
Lin, Wei-Hsin Chang, Yi-Wen Hong, Min-Xiang Hsu, Te-Cheng Lee, Ko-Chuan Lin, Che Lee, Jia-Lin
Published in
Oncogene
Epithelial–mesenchymal transition (EMT)/mesenchymal–epithelial transition (MET) processes are proposed to be a driving force of cancer metastasis. By studying metastasis in bone marrow-derived mesenchymal stem cell (BM-MSC)-driven lung cancer models, microarray time-series data analysis by systems biology approaches revealed BM-MSC-induced signalin...
