Yu, Zeyuan Jiang, Xiangyan Qin, Long Deng, Haixiao Wang, Jianli Ren, Wen Li, Hongbin Zhao, Lei Liu, Huanxiang Yan, Hong
...
Published in
Oncogene
Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficiently efficacious for GC. Thus, we screened new pot...
Periyasamy, Manikandan Singh, Anup K Gemma, Carolina Farzan, Raed Allsopp, Rebecca C Shaw, Jacqueline A Charmsaz, Sara Young, Leonie S Cunnea, Paula Coombes, R Charles
...
Published in
Oncogene
The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels, and consequently limiting cancer mutagenesis. We...
Grossman, Joseph E. Vasudevan, Divya Joyce, Cailin E. Hildago, Manuel
Published in
Oncogene
Zhang, Xin Liu, Yi Dai, Lei Shi, Gang Deng, Jie Luo, Qiang Xie, Qian Cheng, Lin Li, Chunlei Lin, Yi
...
Published in
Oncogene
The basic leucine zipper ATF-like transcription factor 2 (BATF2) has been implicated in inflammatory responses and anti-tumour effects. Little, however, is known regarding its extracellular role in maintaining a non-supportive cancer microenvironment. Here, we show that BATF2 inhibits glioma growth and myeloid-derived suppressor cells (MDSCs) recru...
Poorebrahim, Mansour Melief, Jeroen Pico de Coaña, Yago L Wickström, Stina Cid-Arregui, Angel Kiessling, Rolf
Published in
Oncogene
In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Exhaustion and senescence are two critical dysfuncti...
Formaggio, Nicolò Rubin, Mark A. Theurillat, Jean-Philippe
Published in
Oncogene
Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully implemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increa...
Chen, Huang Bian, Aiwu Yang, Lian-fang Yin, Xuan Wang, Jie Ti, Chaowen Miao, Ying Peng, Shihong Xu, Shifen Liu, Mingyao
...
Published in
Oncogene
Pancreatic cancer is lethal in over 90% of cases since it is resistant to current therapeutic strategies. The key role of STAT3 in promoting pancreatic cancer progression has been proven, but effective interventions that suppress STAT3 activities are limited. The development of novel anticancer agents that directly target STAT3 may have potential c...
Xiao, Yinan Jin, Ling Deng, Chaolin Guan, Ye Kalogera, Eleftheria Ray, Upasana Thirusangu, Prabhu Staub, Julie Sarkar Bhattacharya, Sayantani Xu, Haotian
...
Published in
Oncogene
The advanced or recurrent endometrial cancer (EC) has a poor prognosis because of chemoresistance. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a glycolytic enzyme, is overexpressed in a variety of human cancers and plays important roles in promoting tumor cell growth. Here, we showed that high expression of PFKFB3 in EC cell li...
Pantano, Francesco Croset, Martine Driouch, Keltouma Bednarz-Knoll, Natalia Iuliani, Michele Ribelli, Giulia Bonnelye, Edith Wikman, Harriet Geraci, Sandra Bonin, Florian
...
Published in
Oncogene
Bone metastasis remains a major cause of mortality and morbidity in breast cancer. Therefore, there is an urgent need to better select high-risk patients in order to adapt patient’s treatment and prevent bone recurrence. Here, we found that integrin alpha5 (ITGA5) was highly expressed in bone metastases, compared to lung, liver, or brain metastases...
Al-Akhrass, Hussein Conway, James R. W. Poulsen, Annemarie Svane Aavild Paatero, Ilkka Kaivola, Jasmin Padzik, Artur Andersen, Olav M. Ivaska, Johanna
Published in
Oncogene
Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted therapies is frequently associated with HER3 and active signaling via HER2-HER3 dimers, particularly in the context of breast cancer. Thus, understanding the response to HER2-HER3 signaling and the regulation of the dimer is essential to dec...
