Wang, Xianqiang Wang, Denghui Xu, Wenjian Kong, Lingfei Ye, Xiao Zhuang, Qianye Fan, Di Luo, Keming
Published in
Nucleic acids research
Secondary wall thickening in the sclerenchyma cells is strictly controlled by a complex network of transcription factors in vascular plants. However, little is known about the epigenetic mechanism regulating secondary wall biosynthesis. In this study, we identified that ARABIDOPSIS HOMOLOG of TRITHORAX1 (ATX1), a H3K4-histone methyltransferase, med...
Xin, Junyi Du, Mulong Jiang, Xia Wu, Yanling Ben, Shuai Zheng, Rui Chu, Haiyan Li, Shuwei Zhang, Zhengdong Wang, Meilin
...
Published in
Nucleic acids research
PIWI-interacting RNAs (piRNAs) are an emerging class of non-coding RNAs involved in tumorigenesis. Expression quantitative trait locus (eQTL) analysis has been demonstrated to help reveal the genetic mechanism of single nucleotide polymorphisms (SNPs) in cancer etiology. However, there are no databases that have been constructed to provide an eQTL ...
Smith, Ewan M Benbahouche, Nour El Houda Morris, Katherine Wilczynska, Ania Gillen, Sarah Schmidt, Tobias Meijer, Hedda A Jukes-Jones, Rebekah Cain, Kelvin Jones, Carolyn
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Published in
Nucleic acids research
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achieved, in part, via the co-ordinated regulation of mRNAs that contain a terminal oligopyrimidine tract (TOP) at ...
Zhu, Zhesi Han, Zhen Halabelian, Levon Yang, Xiangkun Ding, Jun Zhang, Nawei Ngo, Liza Song, Jiabao Zeng, Hong He, Maomao
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Published in
Nucleic acids research
Short-chain acylations of lysine residues in eukaryotic proteins are recognized as essential posttranslational chemical modifications (PTMs) that regulate cellular processes from transcription, cell cycle, metabolism, to signal transduction. Lysine butyrylation was initially discovered as a normal straight chain butyrylation (Knbu). Here we report ...
Gao, Yanqing Liu, Hehua Zhang, Chong Su, Shichen Chen, Yiqing Chen, Xi Li, Yangyang Shao, Zhiwei Zhang, Yixi Shao, Qiyuan
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Published in
Nucleic acids research
Infection with kinetoplastid parasites, including Trypanosoma brucei (T. brucei), Trypanosoma cruzi (T. cruzi) and Leishmania can cause serious disease in humans. Like other kinetoplastid species, mRNAs of these disease-causing parasites must undergo posttranscriptional editing in order to be functional. mRNA editing is directed by gRNAs, a large g...
Bacolla, Albino Sengupta, Shiladitya Ye, Zu Yang, Chunying Mitra, Joy De-Paula, Ruth B Hegde, Muralidhar L Ahmed, Zamal Mort, Matthew Cooper, David N
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Published in
Nucleic acids research
Human genome stability requires efficient repair of oxidized bases, which is initiated via damage recognition and excision by NEIL1 and other base excision repair (BER) pathway DNA glycosylases (DGs). However, the biological mechanisms underlying detection of damaged bases among the million-fold excess of undamaged bases remain enigmatic. Indeed, m...
Vigouroux, Armelle Meyer, Thibault Naretto, Anaïs Legrand, Pierre Aumont-Nicaise, Magali Di Cicco, Aurélie Renoud, Sébastien Doré, Jeanne Lévy, Daniel Vial, Ludovic
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Published in
Nucleic acids research
A species-specific region, denoted SpG8-1b allowing hydroxycinnamic acids (HCAs) degradation is important for the transition between the two lifestyles (rhizospheric versus pathogenic) of the plant pathogen Agrobacterium fabrum. Indeed, HCAs can be either used as trophic resources and/or as induced-virulence molecules. The SpG8-1b region is regulat...
Jin, Xin Sun, Tingting Zhao, Chuanke Zheng, Yongxiang Zhang, Yufan Cai, Weijing He, Qiuchen Taira, Kaz Zhang, Lihe Zhou, Demin
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Published in
Nucleic acids research
Kalinina, Marina Skvortsov, Dmitry Kalmykova, Svetlana Ivanov, Timofei Dontsova, Olga Pervouchine, Dmitri D
Published in
Nucleic acids research
The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor function that depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7b. We report that the molecular mechanism underlying MXE splicing in Ate1 involves five conserved regulatory intronic elements R1-R5, of which R1 and R4 compete fo...
Wu, Jian Zhou, Cuiji Li, James Li, Chun Tao, Xiaorong Leontis, Neocles B Zirbel, Craig L Bisaro, David M Ding, Biao
Published in
Nucleic acids research
