Agyei, Paunel Chen, Michelle Guo, Yong Pérez, Carlos A Dubey, Divyanshu Gupta, Rajesh K
Published in
Neurology
Kelch-like protein-11 (KLHL11) immunoglobulin G (IgG) is a recently reported paraneoplastic autoantibody associated with rhombencephalitis, which commonly presents with ataxia, diplopia, vertigo, hearing loss, tinnitus, and gaze palsies. The association of this high-risk paraneoplastic autoantibody with testicular germ cell tumors is widely accepte...
Lail, Gurnoor Siu, Victoria M Leung, Andrew
Published in
Neurology
We describe the case of a 19-month-old girl presenting with gross motor delays, hypotonia, diminished deep tendon reflexes, hyperCKaemia, extensive white matter changes on MRI brain, and electromyography studies consistent with myopathy. The differential diagnosis for infantile-onset hypotonia and muscle weakness is broad. It includes numerous subt...
Nguyen, Hai V Mital, Shweta Knopman, David S Alexander, G Caleb
Published in
Neurology
Little is known regarding the cost-effectiveness of lecanemab (Leqembi), a monoclonal antibody approved by the US Food and Drug Administration in January 2023 for the treatment of mild cognitive impairment (MCI) or mild dementia due to Alzheimer disease (AD). This study aims to quantify the cost-effectiveness of lecanemab and how it varies based on...
Sun, Yuyao Pahwa, Shivani Vasireddy, Rani Priyanka Barty, Andrew Raslau, Flavius D
Published in
Neurology
Bibrachial amyotrophy signifies a clinical phenotype characterized by weakness in both upper extremities with preserved strength in the face, neck, and lower extremities. The underlying causes of bibrachial amyotrophy are broad. We report a patient exhibiting bibrachial amyotrophy who initially received a diagnosis of amyotrophic lateral sclerosis ...
Nelson, Sarah E Lopez, Oscar L
Published in
Neurology
Rajan, Kumar B Mcaninch, Elizabeth A Wilson, Robert S Dhana, Anisa Evans-Lacko, Sara Evans, Denis A
Published in
Neurology
The association of statin initiation with incident Alzheimer disease (AD) dementia and cognitive decline by the APOE ε4 allele is unknown. Our objective was to examine whether the association of statin initiation with incident AD dementia and cognitive decline differs by the APOE ε4 allele. This population-based longitudinal cohort study was conduc...
Comella, Cynthia L Jankovic, Joseph Hauser, Robert A Patel, Atul T Banach, Marta D Ehler, Edvard Vitarella, Domenico Rubio, Roman G Gross, Todd M
Published in
Neurology
ASPEN-1 was a phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, duration of response, and safety of 2 doses of DaxibotulinumtoxinA for Injection (DAXI), a novel botulinum toxin type A formulation in participants with cervical dystonia (CD). Adults (aged 18-80 years) with moderate-to-severe CD (Toronto Western Spa...
Sanders, Maurits W Van der Wolf, Iskander Jansen, Floor E Aronica, Eleonora Helmstaedter, Christoph Racz, Attila Surges, Rainer Grote, Alexander Becker, Albert J Rheims, Sylvain
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Published in
Neurology
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology...
Radzik, Anne Marie Amezcua, Lilyana Anderson, Annika Gilmore, Serena Ahmad, Sophie Brandstadter, Rachel Fabian, Michelle T Graham, Edith L Hodgkinson, Sophia Horton, Lindsay
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Published in
Neurology
Racial disparities exist in both neurologic and obstetric populations, underscoring the importance of evaluating pregnancy outcomes in diverse women with multiple sclerosis (MS). The objective of this multicenter retrospective study was to compare pregnancy care and outcomes between Black and Hispanic (underrepresented) and White women with MS. Dem...
Moglia, Cristina Calvo, Andrea Canosa, Antonio Manera, Umberto Vasta, Rosario Di Pede, Francesca Daviddi, Margherita Matteoni, Enrico Brunetti, Maura Sbaiz, Luca
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Published in
Neurology
TARDBP patients are considered particularly prone to cognitive involvement, but no systematic studies of cognitive impairment in TARDBP patients are available. The aim of this article was to depict in depth the cognitive-behavioral characteristics of a cohort of patients with amyotrophic lateral sclerosis (ALS) carrying TARDBP pathogenetic variants...
