Hengartner, Tobias Adams, Mark Pfister, Riccardo E. Snyers, Diane McDougall, Jane Waldvogel, Salome Held-Egli, Katrin Spring, Lea Rogdo, Bjarte Riedel, Thomas
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Published in
Neonatology
Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestationa...
Kaplan, Michael Hammerman, Cathy
Published in
Neonatology
Ng, Pak Cheung Chan, Kathy Yuen Yee Lam, Hugh Simon Wong, Raymond Pui On Ma, Terence Ping Yuen Sit, Tony Leung, Kam Tong Chan, Lawrence Chi Ngong Pang, Yennie Lap Ian Cheung, Hon Ming
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Published in
Neonatology
Objective: The objective of this study is to evaluate the usefulness of fecal microRNA (miR)-223 and miR-451a, as novel noninvasive biomarkers for early diagnosis of necrotizing enterocolitis (NEC) in preterm infants. Methods: Among the top-listed target miRNAs in our previous differential microarray analysis, miR-223 and miR-451a were quantified i...
Mayock, Dennis E. Xie, Zimeng Comstock, Bryan A. Heagerty, Patrick J. Juul, Sandra E.
Published in
Neonatology
Introduction: The Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial sought to determine the safety and efficacy of early high-dose Epo as a potential neuroprotective treatment. We hypothesized that Epo would not increase the incidence or severity of retinopathy of prematurity (ROP). Methods: A total of 941 infants born between 24–0/7 and 2...
Omer, Murwan Melo, Ashanty Maggvie Kelly, Lynne Mac Dermott, Emma Jane Leahy, Timothy Ronan Killeen, Orla Saugstad, Ola Didrik Savani, Rashmin C. Molloy, Eleanor J.
Published in
Neonatology
Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding...
van Weteringen, Willem van Essen, Tanja Gangaram-Panday, Norani H. Goos, Tom G. de Jonge, Rogier C.J. Reiss, Irwin K.M.
Published in
Neonatology
Introduction: Traditional transcutaneous oxygen (tcPO2) measurements are affected by measurement drift, limiting accuracy and usability. The new potentially drift-free oxygen fluorescence quenching technique has been combined in a single sensor with conventional transcutaneous carbon dioxide (tcPCO2) monitoring. This study aimed to validate optical...
Bahr, Timothy M. Lozano-Chinga, Michell Agarwal, Archana M. Meznarich, Jessica A. Yost, Christian C. Li, Peng Reading, N. Scott Prchal, Josef T. Christensen, Robert D.
Published in
Neonatology
We report a novel glucose-6-phosphate dehydrogenase (G6PD) variant (c.1375C>G) discovered in a 3-day-old Hispanic male child from Salt Lake City, UT, USA. This newborn presented with severe hyperbilirubinemia (29.8 mg/dL or 510 μmol/L) and marked hemolysis evidenced by elevated end-tidal carbon monoxide concentration (5.9 ppm, normal
Allegaert, Karel Smits, Anne Mekahli, Djalila van den Anker, John N.
Published in
Neonatology
Background: Serum creatinine (Scr) in early neonatal life (first week of life) displays extensive variability; hence, a better understanding is needed to use Scr as a diagnostic biomarker for acute kidney injury (AKI). Objective: The objective of this study was to explore Scr trends and its covariates in early neonatal life. Methods: Analysis of a ...
Labuz, Daniel F Asch, Morris J Buchmiller, Terry L
Published in
Neonatology
Gastroschisis is a congenital abdominal wall defect that, when simple, has excellent overall outcomes. However, morbidity increases with prematurity. A staged approach to closure is often needed until the infant can tolerate definitive repair. We demonstrate the novel use of cadaveric skin allograft as a defect patch, exploiting a tolerant neonatal...
Bhatia, Ashwani Chua, Mei Chien dela Puerta, Rowena Rajadurai, Victor Samuel
Published in
Neonatology
Background: Hemolytic hyperbilirubinemia due to blood group incompatibility or glucose-6-phosphate dehydrogenase deficiency (G6PD) is a common cause of significant hyperbilirubinemia. Hemolysis in a hyperbilirubinemic infant increases the risk of bilirubin neurotoxicity. A new portable device (CoSense) can rapidly detect breath end-tidal carbon mon...