Shields, Beverley M Angwin, Catherine D Shepherd, Maggie H Britten, Nicky Jones, Angus G Sattar, Naveed Holman, Rury Pearson, Ewan R Hattersley, Andrew T
Published in
Nature medicine
Patient preference is key for medication selection in chronic medical conditions, like type 2 diabetes, where there are many different drugs available. Patient preference balances potential efficacy with potential side effects. As both aspects of drug response can vary markedly between individuals this decision could be informed by the patient pers...
Shields, Beverley M Dennis, John M Angwin, Catherine D Warren, Fiona Henley, William E Farmer, Andrew J Sattar, Naveed Holman, Rury R Jones, Angus G Pearson, Ewan R
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Published in
Nature medicine
Precision medicine aims to treat an individual based on their clinical characteristics. A differential drug response, critical to using these features for therapy selection, has never been examined directly in type 2 diabetes. We tested two hypotheses: 1) individuals with BMI>30kg/m2, compared with BMI ≤30kg/m2, have greater glucose lowering with t...
Guida, Florence Kidman, Rachel Ferlay, Jacques Schüz, Joachim Soerjomataram, Isabelle Kithaka, Benda Ginsburg, Ophira Mailhot Vega, Raymond B Galukande, Moses Parham, Groesbeck
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Published in
Nature medicine
Despite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the resulting maternal orphans, who experience health and education disadvantages throughout their lives. We estimated the number of children who became maternal orphans in 2020 due to their mother dying from cancer in that year, for 185 ...
Attia, Zachi I Harmon, David M Dugan, Jennifer Manka, Lukas Lopez-Jimenez, Francisco Lerman, Amir Siontis, Konstantinos C Noseworthy, Peter A Yao, Xiaoxi Klavetter, Eric W
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Published in
Nature medicine
Although artificial intelligence (AI) algorithms have been shown to be capable of identifying cardiac dysfunction, defined as ejection fraction (EF) ≤ 40%, from 12-lead electrocardiograms (ECGs), identification of cardiac dysfunction using the single-lead ECG of a smartwatch has yet to be tested. In the present study, a prospective study in which p...
Cliff, Edward R Scheffer Merryman, Reid W Armand, Philippe Jacobson, Caron A
Published in
Nature medicine
Hajek, Peter Przulj, Dunja Pesola, Francesca Griffiths, Chris Walton, Robert McRobbie, Hayden Coleman, Tim Lewis, Sarah Whitemore, Rachel Clark, Miranda
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Published in
Nature medicine
Ng, Madelena Y Kapur, Supriya Blizinsky, Katherine D Hernandez-Boussard, Tina
Published in
Nature medicine
Garofalo, Michela Romano, Giulia Di Leva, Gianpiero Nuovo, Gerard Jeon, Young-Jun Ngankeu, Apollinaire Sun, Jin Lovat, Francesca Alder, Hansjuerg Condorelli, Gerolama
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Published in
Nature medicine
Gunst, Jesper D Pahus, Marie H Rosás-Umbert, Miriam Lu, I-Na Benfield, Thomas Nielsen, Henrik Johansen, Isik S Mohey, Rajesh Østergaard, Lars Klastrup, Vibeke
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Published in
Nature medicine
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-group factorial design, we investigated whether early intervention in newly diagnosed people with HIV-1 ...
Simpson, Rebecca C Shanahan, Erin R Batten, Marcel Reijers, Irene L M Read, Mark Silva, Ines P Versluis, Judith M Ribeiro, Rosilene Angelatos, Alexandra S Tan, Jian
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Published in
Nature medicine
The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer, however dietary and geographic influences have not been well-studied in prospective trials. To address this, we prospectively profiled baseline gut (fecal) microbiota signatures and dietary patterns of 103 trial patients from Australia and the Netherlands treat...
