Haimon, Zhana Volaski, Alon Orthgiess, Johannes Boura-Halfon, Sigalit Varol, Diana Shemer, Anat Yona, Simon Zuckerman, Binyamin David, Eyal Chappell-Maor, Louise
...
Published in
Nature immunology
Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain's macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcriptome sequencing and the 'RiboTag...
Dunning, Jake Blankley, Simon Hoang, Long T Cox, Mike Graham, Christine M James, Philip L Bloom, Chloe I Chaussabel, Damien Banchereau, Jacques Brett, Stephen J
...
Published in
Nature immunology
Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data we...
Machiels, Bénédicte Dourcy, Mickael Xiao, Xue Javaux, Justine Mesnil, Claire Sabatel, Catherine Desmecht, Daniel Lallemand, François Martinive, Philippe Hammad, Hamida
...
Published in
Nature immunology
The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4...
Rubelt, Florian Busse, Christian E Bukhari, Syed Ahmad Chan Bürckert, Jean-Philippe Mariotti-Ferrandiz, Encarnita Cowell, Lindsay G Watson, Corey T Marthandan, Nishanth Faison, William J Hershberg, Uri
...
Published in
Nature immunology
Delacher, Michael Imbusch, Charles D Weichenhan, Dieter Breiling, Achim Hotz-Wagenblatt, Agnes Träger, Ulrike Hofer, Ann-Cathrin Kägebein, Danny Wang, Qi Frauhammer, Felix
...
Published in
Nature immunology
Regulatory T cells (Treg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue Treg cells. We found that epigenetic modifications defined the molecular characteristics of tissue Treg cells. Tagmentation-based whole-genome bisulfite sequencing revealed more ...
Kim, Sun Jung Schätzle, Sebastian Ahmed, S Sohail Haap, Wolfgang Jang, Su Hwa Gregersen, Peter K Georgiou, George Diamond, Betty
Published in
Nature immunology
Aberrant population expansion of follicular helper T cells (TFH cells) occurs in patients with lupus. An unanswered question is whether an altered repertoire of T cell antigen receptors (TCRs) is associated with such expansion. Here we found that the transcription factor Blimp-1 (encoded by Prdm1) repressed expression of the gene encoding cathepsin...
Ganesan, Anusha-Preethi Clarke, James Wood, Oliver Garrido-Martin, Eva M Chee, Serena J Mellows, Toby Samaniego-Castruita, Daniela Singh, Divya Seumois, Grégory Alzetani, Aiman
...
Published in
Nature immunology
Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients with lung ca...
Dolezal, Elmar Infantino, Simona Drepper, Friedel Börsig, Theresa Singh, Aparajita Wossning, Thomas Fiala, Gina J Minguet, Susana Warscheid, Bettina Tarlinton, David M
...
Published in
Nature immunology
Developing pre-B cells in the bone marrow alternate between proliferation and differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell translocation gene 2 (BTG2) are critical components of the pre-B cell differentiation program. The BTG2-PRMT1 module induced a cell-cycle arrest of pre-B cells that was accompan...
Dempsey, Laurie A
Published in
Nature immunology
Amsen, Derk Hombrink, Pleun van Lier, Rene A W
Published in
Nature immunology