Halbertal, Dorri Turkel, Simon Ciccarino, Christopher J Hauck, Jonas B Finney, Nathan Hsieh, Valerie Watanabe, Kenji Taniguchi, Takashi Hone, James Dean, Cory
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Published in
Nature communications
The electronic and structural properties of atomically thin materials can be controllably tuned by assembling them with an interlayer twist. During this process, constituent layers spontaneously rearrange themselves in search of a lowest energy configuration. Such relaxation phenomena can lead to unexpected and novel material properties. Here, we s...
Erven, Ilka Abraham, Elena Hermanns, Thomas Baumann, Ulrich Hofmann, Kay
Published in
Nature communications
Distinct families of eukaryotic deubiquitinases (DUBs) are regulators of ubiquitin signaling. Here, we report on the presence of an additional DUB class broadly distributed in eukaryotes and several bacteria. The only described members of this family are the large tegument proteins of herpesviruses, which are attached to the outside of the viral ca...
Ji, Ming-Liang Jiang, Hua Li, Zhuang Geng, Rui Hu, Jun Zheng Lin, Yu Cheng Lu, Jun
Published in
Nature communications
Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined. Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas in...
Chan, Louisa L Y Anderson, Danielle E Cheng, Hong Sheng Ivan, Fransiskus Xaverius Chen, Si Kang, Adrian E Z Foo, Randy Gamage, Akshamal M Tiew, Pei Yee Koh, Mariko Siyue
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Published in
Nature communications
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and infective exacerbations, however, in-vitro model systems for the study of host-pathogen interaction at the individual level are lacking. Here, we describe the establishment of nasopharyngeal and bronchial organoids from healthy individuals and COPD that recapitu...
Spreacker, Peyton J Thomas, Nathan E Beeninga, Will F Brousseau, Merissa Porter, Colin J Hibbs, Kylie M Henzler-Wildman, Katherine A
Published in
Nature communications
Small multidrug resistance (SMR) transporters contribute to antibiotic resistance through proton-coupled efflux of toxic compounds. Previous biophysical studies of the E. coli SMR transporter EmrE suggest that it should also be able to perform proton/toxin symport or uniport, leading to toxin susceptibility rather than resistance in vivo. Here we s...
Shen, Rongbo Liu, Lin Wu, Zihan Zhang, Ying Yuan, Zhiyuan Guo, Junfu Yang, Fan Zhang, Chao Chen, Bichao Feng, Wanwan
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Published in
Nature communications
Spatially resolved transcriptomics provides the opportunity to investigate the gene expression profiles and the spatial context of cells in naive state, but at low transcript detection sensitivity or with limited gene throughput. Comprehensive annotating of cell types in spatially resolved transcriptomics to understand biological processes at the s...
Xu, Xiaolong Yang, Shiqi Wang, Huan Guzman, Roger Gao, Yuchen Zhu, Yaozheng Peng, Yuxuan Zang, Zhihao Xi, Ming Tian, Shangjie
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Published in
Nature communications
Natural superlattice structures MnBi2Te4(Bi2Te3)n (n = 1, 2, ...), in which magnetic MnBi2Te4 layers are separated by nonmagnetic Bi2Te3 layers, hold band topology, magnetism and reduced interlayer coupling, providing a promising platform for the realization of exotic topological quantum states. However, their magnetism in the two-dimensional limit...
Lian, Xu Zhao, Wenli Gentine, Pierre
Published in
Nature communications
Evaporative loss of interception (Ei) is the first process occurring during rainfall, yet its role in large-scale surface water balance has been largely underexplored. Here we show that Ei can be inferred from flux tower evapotranspiration measurements using physics-informed hybrid machine learning models built under wet versus dry conditions. Forc...
Gjelstrup, Caroline V B Sejr, Mikael K de Steur, Laura Christiansen, Jørgen Schou Granskog, Mats A Koch, Boris P Møller, Eva Friis Winding, Mie H S Stedmon, Colin A
Published in
Nature communications
The Northeast Greenland shelf (NEGS) is a recipient of Polar Water (PW) from the Arctic Ocean, Greenland Ice Sheet melt, and Atlantic Water (AW). Here, we compile hydrographical measurements to quantify long-term changes in fjords and coastal waters. We find a profound change in the vertical distribution of water masses, with AW shoaling >60 m and ...
Charpignon, Marie-Laure Vakulenko-Lagun, Bella Zheng, Bang Magdamo, Colin Su, Bowen Evans, Kyle Rodriguez, Steve Sokolov, Artem Boswell, Sarah Sheu, Yi-Han
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Published in
Nature communications
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may alter dementia onset. Mixed results are emerging from prior observational studies. To address this complexity, we deploy a causal inference approach accounting for the competing risk of death in emulated clinical trials using two distinct electronic health r...
