Montnach, Jérôme Blömer, Laila Ananda Lopez, Ludivine Filipis, Luiza Meudal, Hervé Lafoux, Aude Nicolas, Sébastien Chu, Duong Caumes, Cécile Béroud, Rémy
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Published in
Nature communications
Photoactivatable drugs targeting ligand-gated ion channels open up new opportunities for light-guided therapeutic interventions. Photoactivable toxins targeting ion channels have the potential to control excitable cell activities with low invasiveness and high spatiotemporal precision. As proof-of-concept, we develop HwTxIV-Nvoc, a UV light-cleavab...
Li, Xiangying Wang, Ninglian Ding, Yongjian Hawkings, Jon R Yde, Jacob C Raiswell, Robert Liu, Jintao Zhang, Shiqiang Kang, Shichang Wang, Rongjun
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Published in
Nature communications
Physical erosion and chemical weathering rates beneath glaciers are expected to increase in a warming climate with enhanced melting but are poorly constrained. We present a global dataset of cations in meltwaters of 77 glaciers, including new data from 19 Asian glaciers. Our study shows that contemporary cation denudation rates (CDRs) beneath glaci...
Ortega-Hernández, Javier Lerosey-Aubril, Rudy Losso, Sarah R Weaver, James C
Published in
Nature communications
Recent years have witnessed a steady increase in reports of fossilized nervous tissues among Cambrian total-group euarthropods, which allow reconstructing the early evolutionary history of these animals. Here, we describe the central nervous system of the stem-group chelicerate Mollisonia symmetrica from the mid-Cambrian Burgess Shale. The fossiliz...
Sung, Suk Hyun Schnitzer, Noah Novakov, Steve El Baggari, Ismail Luo, Xiangpeng Gim, Jiseok Vu, Nguyen M Li, Zidong Brintlinger, Todd H Liu, Yu
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Published in
Nature communications
Compelling evidence suggests distinct correlated electron behavior may exist only in clean 2D materials such as 1T-TaS2. Unfortunately, experiment and theory suggest that extrinsic disorder in free standing 2D layers disrupts correlation-driven quantum behavior. Here we demonstrate a route to realizing fragile 2D quantum states through endotaxial p...
Ye, Tian Zhang, Feng-Lian Xia, Hui-Min Zhou, Xi Yu, Zhi-Xiang Wang, Yi-Feng
Published in
Nature communications
Radical cascade reactions are powerful tools to construct structurally complex molecules. However, the stereochemical control of acyclic radical intermediates remains a persistent challenge, due to the low differentiation between the two faces of these species. This hurdle further makes stereodivergent synthesis rather more difficult to be accompli...
Dai, Bingyang Xu, Jiankun Li, Xu Huang, Le Hopkins, Chelsea Wang, Honglian Yao, Hao Mi, Jie Zheng, Lizhen Wang, Jiali
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Published in
Nature communications
Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone metabolism are not well understood. Here, we report that macrophages in eWAT are a main source of osteopontin, which selectively circulates to the bone marrow and prom...
Maan, Harsh Itkin, Maxim Malitsky, Sergey Friedman, Jonathan Kolodkin-Gal, Ilana
Published in
Nature communications
Microbial communities employ a variety of complex strategies to compete successfully against competitors sharing their niche, with antibiotic production being a common strategy of aggression. Here, by systematic evaluation of four non-ribosomal peptides/polyketide (NRPs/PKS) antibiotics produced by Bacillus subtilis clade, we revealed that they act...
Zhang, Xiaojuan Yang, Yutong Ding, Jiahao Zhao, Yun Zhang, Hongbin Zhu, Yugen
Published in
Nature communications
Glycosyl phosphosaccharides represent a large and important family of complex glycans. Due to the distinct nature of these complex molecules, efficient approaches to access glycosyl phosphosaccharides are still in great demand. Here, we disclose a highly efficient and stereoselective approach to the synthesis of biologically important and complex α...
Lai, Francisco Tsz Tsun Huang, Lei Chui, Celine Sze Ling Wan, Eric Yuk Fai Li, Xue Wong, Carlos King Ho Chan, Edward Wai Wa Ma, Tiantian Lum, Dawn Hei Leung, Janice Ching Nam
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Published in
Nature communications
Prior research using electronic health records for Covid-19 vaccine safety monitoring typically focuses on specific disease groups and excludes individuals with multimorbidity, defined as ≥2 chronic conditions. We examine the potential additional risk of adverse events 28 days after the first dose of CoronaVac or Comirnaty imposed by multimorbidity...
Pearce, Nicholas Reynolds, Katherine E A Kayal, Surajit Sun, Xue Z Davies, E Stephen Malagreca, Ferdinando Schürmann, Christian J Ito, Sho Yamano, Akihito Argent, Stephen P
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Published in
Nature communications
The ability to control photoinduced charge transfer within molecules represents a major challenge requiring precise control of the relative positioning and orientation of donor and acceptor groups. Here we show that such photoinduced charge transfer processes within homo- and hetero-rotaxanes can be controlled through organisation of the components...
