Sandoz, Jérémy Cigrang, Max Zachayus, Amélie Catez, Philippe Donnio, Lise-Marie Elly, Clèmence Nieminuszczy, Jadwiga Berico, Pietro Braun, Cathy Alekseev, Sergey
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Published in
Nature communications
The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 nuclease impairs RRS and decreases cell survival after UV irradiation, without affecting DNA repair. Overexpression of wild-type, but not nuclease-dead EXD2, restores RRS ...
Legier, Thomas Rattier, Diane Llewellyn, Jack Vannier, Thomas Sorre, Benoit Maina, Flavio Dono, Rosanna
Published in
Nature communications
The processes of primitive streak formation and fate specification in the mammalian epiblast rely on complex interactions between morphogens and tissue organization. Little is known about how these instructive cues functionally interact to regulate gastrulation. We interrogated the interplay between tissue organization and morphogens by using human...
Ayers, Katie L Eggers, Stefanie Rollo, Ben N Smith, Katherine R Davidson, Nadia M Siddall, Nicole A Zhao, Liang Bowles, Josephine Weiss, Karin Zanni, Ginevra
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Published in
Nature communications
Squamous cell carcinoma antigen recognized by T cells 3 (SART3) is an RNA-binding protein with numerous biological functions including recycling small nuclear RNAs to the spliceosome. Here, we identify recessive variants in SART3 in nine individuals presenting with intellectual disability, global developmental delay and a subset of brain anomalies,...
de Melo, Guilherme Dias Perraud, Victoire Alvarez, Flavio Vieites-Prado, Alba Kim, Seonhee Kergoat, Lauriane Coleon, Anthony Trüeb, Bettina Salome Tichit, Magali Piazza, Aurèle
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Published in
Nature communications
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has changed, with anosmia being less frequent. Here, we assessed the clinical, olfactory and neuroinflammatory conditions of golden hamsters infected with the original Wuhan...
Delage, Laure Carbone, Francesco Riller, Quentin Zachayus, Jean-Luc Kerbellec, Erwan Buzy, Armelle Stolzenberg, Marie-Claude Luka, Marine de Cevins, Camille Kalouche, Georges
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Published in
Nature communications
Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion of patients with GPS develop autoimmunity through an unknown mechanism, which might be related to the proteins NBEAL2 interacts with, specifically in immune cells. Here we show a ...
Feurtey, Alice Lorrain, Cécile McDonald, Megan C Milgate, Andrew Solomon, Peter S Warren, Rachael Puccetti, Guido Scalliet, Gabriel Torriani, Stefano F F Gout, Lilian
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Published in
Nature communications
Human activity impacts the evolutionary trajectories of many species worldwide. Global trade of agricultural goods contributes to the dispersal of pathogens reshaping their genetic makeup and providing opportunities for virulence gains. Understanding how pathogens surmount control strategies and cope with new climates is crucial to predicting the f...
van der Woude, Auke M Peters, Wouter Joetzjer, Emilie Lafont, Sébastien Koren, Gerbrand Ciais, Philippe Ramonet, Michel Xu, Yidi Bastos, Ana Botía, Santiago
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Published in
Nature communications
The year 2022 saw record breaking temperatures in Europe during both summer and fall. Similar to the recent 2018 drought, close to 30% (3.0 million km2) of the European continent was under severe summer drought. In 2022, the drought was located in central and southeastern Europe, contrasting the Northern-centered 2018 drought. We show, using multip...
Young, William J Haessler, Jeffrey Benjamins, Jan-Walter Repetto, Linda Yao, Jie Isaacs, Aaron Harper, Andrew R Ramirez, Julia Garnier, Sophie van Duijvenboden, Stefan
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Published in
Nature communications
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and...
Fostier, Corentin R Ousalem, Farès Leroy, Elodie C Ngo, Saravuth Soufari, Heddy Innis, C Axel Hashem, Yaser Boël, Grégory
Published in
Nature communications
Antibiotic resistance ABC-Fs (ARE ABC-Fs) are translation factors that provide resistance against clinically important ribosome-targeting antibiotics which are proliferating among pathogens. Here, we combine genetic and structural approaches to determine the regulation of streptococcal ARE ABC-F gene msrD in response to macrolide exposure. We show ...
Moreno-Gámez, Stefany Hochberg, Michael E van Doorn, G S
Published in
Nature communications
Bacteria release and sense small molecules called autoinducers in a process known as quorum sensing. The prevailing interpretation of quorum sensing is that by sensing autoinducer concentrations, bacteria estimate population density to regulate the expression of functions that are only beneficial when carried out by a sufficiently large number of c...
