Author Correction: Retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.
Published in Nature medicine
Author Correction: Retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.
Interactions between the lipidome and genetic and environmental factors in autism
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Published in Nature Medicine
Detailed analyses pairing deep phenotyping and molecular profiles reveal mediating roles of plasma lipids in genetic and environmental factors associated with autism-related traits in children.
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.
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Published in Nature medicine
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk...
Incident type 2 diabetes attributable to suboptimal diet in 184 countries
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Published in Nature Medicine
Modeling analysis from the Global Dietary Database estimated that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations.
Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a rando...
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Published in Nature medicine
Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). However, many individuals are unable to collect optimal CD34+ hematopoietic stem and progenitor cell (HSPC) numbers with granulocyte colony-stimulating factor (G-CSF) mobilization. Motixafortide is a novel cyclic-peptide CXCR4 inhibitor with extend...
Concerns about the Burden of Proof studies.
Published in Nature medicine
Reply to: Concerns about the Burden of Proof studies
Published in Nature Medicine
A longitudinal circulating tumor DNA-based model associated with survival in metastatic non-small-cell lung cancer.
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Published in Nature medicine
One of the great challenges in therapeutic oncology is determining who might achieve survival benefits from a particular therapy. Studies on longitudinal circulating tumor DNA (ctDNA) dynamics for the prediction of survival have generally been small or nonrandomized. We assessed ctDNA across 5 time points in 466 non-small-cell lung cancer (NSCLC) p...
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle interventi...
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Published in Nature medicine
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic diseases. Here we report an atlas of cross-sectional and longitudinal changes in 1,111 blood analytes associated with variation in body mass index (BMI), as well as ...
Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results.
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Published in Nature medicine
There is a critical need for effective treatments for leptomeningeal disease (LMD). Here, we report the interim analysis results of an ongoing single-arm, first-in-human phase 1/1b study of concurrent intrathecal (IT) and intravenous (IV) nivolumab in patients with melanoma and LMD. The primary endpoints are determination of safety and the recommen...
