Ultrasound appears to be a reliable technique for the diagnosis of piriformis syndrome
Published in Muscle & Nerve
See editorial on pages 395–396 in this issue .
The myotonic dystrophy experience: a North American cross‐sectional study
Published in Muscle & Nerve
Introduction : Myotonic dystrophy (DM) is a chronic, multisystemic, neurological condition. Patients and caregivers are uniquely suited to identify what symptoms are most important and highlight the unmet needs that are most relevant to DM. Methods : We conducted a North American, cross‐sectional study of people with DM type‐1, congenital DM, and D...
A child with antibody‐negative immune‐mediated necrotizing myopathy
Published in Muscle & Nerve
Regeneration of nerve crush injury using adipose‐derived stem cells: A multimodal comparison
Published in Muscle & Nerve
Introduction : To restore full function following nerve crush injuries is critical but challenging. In an attempt to develop a viable therapy, we evaluated the effect of rat adipose‐derived stem cells (rASC) in 2 different settings of a sciatic crush injury model. Methods : In the first group, after 14 days of nerve crush injury, rASCs were injecte...
Deflazacort versus prednisone/prednisolone for maintaining motor function and delaying loss of ambulation: A post HOC an...
...Published in Muscle & Nerve
Introduction : ACT DMD was a 48‐week trial of ataluren for nonsense mutation Duchenne muscular dystrophy (nmDMD). Patients received corticosteroids for ≥6 months at entry and stable regimens throughout study. This post hoc analysis compares efficacy and safety for deflazacort and prednisone/prednisolone in the placebo arm. Methods : Patients receiv...
Grading the loss of sensation in diabetic patients: A psychometric evaluation of the rotterdam diabetic foot study test ...
Published in Muscle & Nerve
Introduction : Static‐ and moving 2‐point discrimination (S2PD, M2PD), 10‐g monofilaments‐ and tuning fork are validated outcome measures of clinical manifestations of diabetes‐related neuropathy. No modern statistical techniques have been used to investigate how well these instruments combine to measure sensory loss. Methods : To grade sensory los...
CK-2127107 amplifies skeletal muscle response to nerve activation in humans.
Published in Muscle & nerve
Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans. To assess the force-frequency response, participa...
Repeater F-waves are signs of motor unit pathology in polio survivors.
Published in Muscle & nerve
The purpose of this study was to determine whether F-waves reveal electrophysiological features of anterior horn cells in polio survivors. Forty-three polio survivors and 20 healthy controls underwent motor nerve conduction studies of the median and tibial nerves bilaterally, including sampling of F-waves elicited by 100 stimuli and the determinati...
Muscle magnetic resonance imaging sensitivity does not decrease in chronic, mild, or proximal lower limb neuropathies.
...Published in Muscle & Nerve
Muscle MRI is an alternative tool to EMG in proximal, mild, or chronic clinical diagnoses of lower limb focal neuropathies. However, it also seems prone to false-positive results, particularly in proximal muscles.
Multijoint reflexes of the stroke arm: neural coupling of the elbow and shoulder.
Published in Muscle & Nerve
The reflex torque responses of the elbow and shoulder to constant velocity angular extensions of the full comfortable range of the spastic elbow were measured in 16 people with unilateral stroke and 6 neurologically intact controls in order to identify the interjoint reflex coupling that occurs after stroke. The resulting responses showed a substan...
