Huang, Tai-Qin Wang, Yiwei Ebrahem, Quteba Chen, Yu Cheng, Cindy Doughman, Yong Qiu Watanabe, Michiko Dunwoodie, Sally L Yang, Yu-Chung
Published in
Molecular vision
Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators. Cited2 null embryos exhibit hyaloid hypercellularity consisting of aberrant vasculature in the eye. The purpose of the study is to address whether abnormal lenticular development is a prim...
Qu, Juan Matsouaka, Roland Betensky, Rebecca A Hyman, Bradley T Grosskreutz, Cynthia L
Published in
Molecular vision
We previously reported that calcineurin, a Ca(2+)/calmodulin-dependent serine/threonine phosphatase, is activated and proposed that it participates in retinal ganglion cell (RGC) apoptosis in two rodent ocular hypertension models. In this study, we tested whether calcineurin activation by itself, even in the absence of ocular hypertension, is suffi...
Puddu, Alessandra Sanguineti, Roberta Durante, Arianna Nicolò, Massimo Viviani, Giorgio L
Published in
Molecular vision
Neovascularization is a common complication of many degenerative and vascular diseases of the retina. Advanced glycation end-products (AGEs) have a pathologic role in the development of retinal neovascularization, mainly for their ability in upregulating vascular endothelial growth factor-A (VEGF-A) secretion. The aim of this study was to investiga...
Cai, Su-ping Muhemaiti, Paerheti Yin, Yan Cheng, Hongbo Di Ya, A Keyimu, Maliyamu Cao, Xu Fan, Ning Jiang, Liqiong Yan, Naihong
...
Published in
Molecular vision
Our study suggests that the novel mutation D384G of MYOC is likely responsible for the pathogenesis of POAG in this pedigree.
Chen, Hui Wen, Feng Zhang, Xiongze Su, Shao Bo
Published in
Molecular vision
These results indicate a possible role of Th22 cells in DR, and IL-22 may be involved more in the pathogenesis of proliferative diabetic retinopathy than in other stages of DR.
Ha, Yonju Saul, Alan Tawfik, Amany Zorrilla, Eric P Ganapathy, Vadivel Smith, Sylvia B
Published in
Molecular vision
This is the first report showing unequivocally that the neuroprotective effects of (+)-PTZ require σR1. σR1 KO mice show normal retinal structure and function at young ages; however, when subjected to the chronic stress of diabetes, there is an acceleration of retinal functional deficits in σR1 KO mice such that ganglion cell dysfunction is observe...
Yang, Yang Mao, Danna Chen, Xinke Zhao, Ling Tian, Qing Liu, Chenggang Zhou, Bo Lei Shanbi
Published in
Molecular vision
Little is known about retinal neuronal loss in the retinas of diabetic mice. The purpose of this study was the quantitative assessment of retinal neural cell number in diabetic mice. Five-week-old C57BL/6 mice were used as a diabetic model with streptozotocin. Mice were studied over the course of 6 and 12 weeks after the onset of diabetes. Intraocu...
Abu-Amero, Khaled K Azad, Taif Anwar Spaeth, George L Myers, Jonathan Katz, L Jay Moster, Marlene Bosley, Thomas M
Published in
Molecular vision
To investigate the expression level of the optineurin gene (OPTN) in the blood of primary open angle glaucoma (POAG) patients to determine if altered expression is playing a role in primary open angle glaucoma systemically. Patients (n=47) were eligible for inclusion if they met standard clinical criteria for POAG, including age greater than 40 yea...
Dong, Jiamei Bu, Juan Du, Wei Li, Yuan Jia, Yanlei Li, Jianchang Meng, Xiaoli Yuan, Minghui Peng, Xiaojuan Zhou, Aimin
...
Published in
Molecular vision
Screening of mutations in the fibrillin-1 (FBN1) gene in a Chinese family with autosomal dominant Marfan syndrome (MFS). It has been reported that FBN1 mutations account for approximately 90% of Autosomal Dominant MFS. FBN1 mutations were analyzed in a Chinese family of 36 members including 13 MFS patients. The genomic DNAs from blood leukocytes of...
Reddy, Paduru Yadagiri Giridharan, Nappan Veettil Reddy, Geereddy Bhanuprakash
Published in
Molecular vision
Obesity is a major public health problem worldwide, and of late, epidemiological studies indicate a preponderance of cataracts under obesity conditions. Although cataract is a multifactorial disorder and various biochemical mechanisms have been proposed, the influence of obesity on cataractogenesis has yet to be investigated. In such a scenario, a ...
