Araki, Manoel Vinicius Rocha Silva, Yuri Carvalho Oiamore Rodrigues, Thiago Adalton Rosa Bajano, Flavia Fialho de Souza, Bruno Batista Costa, Fernando Ferreira Costa, Vital Paulino de Melo, Mônica Barbosa de Vasconcellos, José Paulo Cabral
Published in
Molecular vision
Glaucoma is the world's leading cause of irreversible blindness, with primary open-angle glaucoma (POAG) being the most prevalent subtype. In recent years, there have been advances in knowledge about the genetics involved in POAG, but genetic studies in admixed populations, such as Brazilians, are still rare. This study aimed to evaluate the associ...
Khateb, Samer Shemesh, Aya Offenheim, Ashly Sheffer, Ruth Ben-Yosef, Tamar Chowers, Itay Leibu, Rina Baumann, Britta Wissinger, Bernd Kohl, Susanne
...
Published in
Molecular vision
Blue cone monochromacy (BCM) is an X-linked retinopathy caused by mutations in the red and green cone opsin genes. The aim of this study was to establish the clinical, genetic, and electrophysiological characteristics of a specific form of BCM. Patients harboring mutations in the OPN1LW/OPN1MW genes underwent a full clinical examination, including ...
Varadaraj, Kulandaiappan Gao, Junyuan Mathias, Richard T Kumari, S Sindhu
Published in
Molecular vision
Glutathione peroxidase 1 (GPX1) and catalase are expressed in the lens epithelial cells and cortical fiber cells, where they detoxify H2O2 to reduce oxidative stress, which is a major cause for cataractogenesis. We sought to find out, between these two enzymes, which is critical for transparency and homeostasis in the aging lens by investigating al...
Liu, Li Jiang, Youde Steinle, Jena J
Published in
Molecular vision
Reactive oxygen species (ROS) activate inflammatory pathways in several organs, including the retina. More recent work has shown that ROS activate the NOD-like receptor protein 3 (NLRP3) inflammasome pathway proteins. We recently showed that the exchange protein activated by cAMP 1 (Epac1) and protein kinase A (PKA) regulates NLRP3 proteins in the ...
Li, Jingwei Cheng, Chao Lin, Tianlan Xue, Ran Liu, Xiuping Wu, Kaili
Published in
Molecular vision
Objective: To investigate the effect of sodium polyanethol sulfonate (SPS) on herpes simplex virus type 1 (HSV-1) infection in vitro. Human corneal epithelial (HCE-T) cells and Vero cells were infected with HSV-1 [HSV-1 f strain, HSV-1f; HSV-1-H129 with green fluorescent protein (GFP) knock-in, HSV-1g]. SPS was added to the culture medium at variou...
Chen, Yuan Zhou, Yixiang Zhu, Xue Yan, Ge Pan, Donghui Wang, Lizhen Yang, Min Wang, Ke
Published in
Molecular vision
Positron emission tomography (PET) is widely used in high-precision imaging, which may provide a simple and noninvasive method for the detection of pathology and therapeutic effects. [18F]-DPA-714 is a second-generation translocator protein (TSPO) positron emission tomography radiotracer that shows great promise in a model of neuroinflammation. In ...
Miloudi, Sofiane Valensi, Maud El Sanharawi, Mohamed Abitbol, Marc M Behar-Cohen, Francine Versaux-Botteri, Claudine
Published in
Molecular vision
Choroidal and retinal neovascularization plays an essential role in various ocular diseases. In this study, we examined the role of nestin in this process. Nestin is an intermediate filament protein known to play several roles, including as a marker of neural progenitor and proliferating endothelial cells. We used Brown Norway rats, in which choroi...
Chu, Kai On Chan, Tina InLam Chan, Kwok Ping Yip, Yolanda WongYing Bakthavatsalam, Malini Wang, Chi Chiu Pang, Chi Pui Brelen, Marten E
Published in
Molecular vision
The mechanism of diabetic macular edema (DME) was explored by comparing the intraocular metabolite profiles of the aqueous humor of patients with DME to those of diabetic patients without DME using untargeted metabolomic analysis. Aqueous samples from 18 type 2 diabetic patients with DME and 18 type 2 diabetic patients without DME used as controls ...
Knight, Lachlan S W Mullany, Sean Taranath, Deepa A Ruddle, Jonathan B Barnett, Christopher P Sallevelt, Suzanne C E H Berry, Ella C Marshall, Henry N Hollitt, Georgina L Souzeau, Emmanuelle
...
Published in
Molecular vision
ADAMTSL4-associated ectopia lentis is a rare autosomal recessive condition that is primarily associated with crystalline lens displacement. However, the prevalence of other ocular and systemic manifestations of this condition is poorly understood. In this study, we summarize the ocular and systemic phenotypic spectrum of this condition. A cross-sec...
Lin, Xiaoli Huang, Xionggao Wang, Ling Liu, Weixian
Published in
Molecular vision
This study was designed to dissect the role of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in retinoblastoma (RB) and its underlying mechanism. Gain- and loss-of-function experiments were adopted to explore the effects of MALAT1 and microRNA (miR)-598-3p on the biologic behaviors of RB cells. Reverse transcrip...
