Nitric oxide: a brake for bad behavior.
Published in Molecular psychiatry
Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs.
Published in Molecular psychiatry
Detection of linkage using a systematic genome scan in nuclear families including an affected sibling pair is an important initial step on the path to cloning susceptibility genes for complex genetic disorders such as bipolar disorder and schizophrenia. We describe a novel method in which the pooled genotype of each affected sib-pair is determined ...
Genes contributing to Alzheimer's disease.
Published in Molecular psychiatry
We propose that Alzheimer's disease (AD) is a single disease with a common metabolic APP-beta A4-amyloid pathway. The multiple genetic and other factors already identified to induce this pathway are reviewed. The molecular genetics of AD has been successfully studied within the last years, and we now can account for the genetic and molecular altera...
Cardiff '95: the late adolescence of psychiatric genetics.
Published in Molecular psychiatry
Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine.
Published in Molecular psychiatry
Dopamine-glutamate interactions within discrete neural circuits are increasingly recognized as potential substrates for dysregulation in schizophrenia, and as a result, potential targets for pharmacological intervention in this illness. We examined the regulation, by haloperidol (2 mg kg-1 day-1) and clozapine (20 mg kg-1 day-1), of the mRNAs encod...
Progress in understanding the pathogenesis of Alzheimer's disease.
Published in Molecular psychiatry
Changes in gene transcription during a beta-mediated cell death.
Published in Molecular psychiatry
The a beta peptide induces cell death in neurons grown in cell culture. Previous studies have shown that the mechanism of a beta-mediated cell death of central nervous system neurons appears to be via apoptosis. Apoptosis is an active process that involves both gene transcription and translation. Using semi-quantitative polymerase chain reaction, w...
Molecular Psychiatry: the integration of molecular medicine and clinical psychiatry.
Published in Molecular psychiatry
Modern molecular genetic approaches to complex traits: implications for psychiatric disorders.
Published in Molecular psychiatry
The majority of common psychiatric disorders pose problems for geneticists because of their complex and non-Mendelian modes of inheritance. Early attempts to map genes for mental illness have so far largely overlooked this and sought genes of major effect in multiplex families using the lod score method of linkage analysis. However it seems that ma...
The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia.
Published in Molecular psychiatry
Changes in cholinergic neurons have been implicated in the pathology of schizophrenia. Clozapine, an atypical anti-psychotic drug, has been shown to bind with high affinity to the muscarinic1 (M1) receptor suggesting this receptor could be involved in the therapeutic efficacy of the drug. Because of this we measured the density of M1 receptors in t...
