Gallina, Irene Hendriks, Ivo A Hoffmann, Saskia Larsen, Nicolai B Johansen, Joachim Colding-Christensen, Camilla S Schubert, Lisa Sellés-Baiget, Selene Fábián, Zita Kühbacher, Ulrike
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Published in
Molecular cell
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis involves either translesion DNA synthesis (TLS) or template switching (TS). Controlling these processes, ubiq...
Hopp, Ann-Katrin Teloni, Federico Bisceglie, Lavinia Gondrand, Corentin Raith, Fabio Nowak, Kathrin Muskalla, Lukas Howald, Anna Pedrioli, Patrick G A Johnsson, Kai
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Published in
Molecular cell
In addition to its role as an electron transporter, mitochondrial nicotinamide adenine dinucleotide (NAD+) is an important co-factor for enzymatic reactions, including ADP-ribosylation. Although mitochondria harbor the most intra-cellular NAD+, mitochondrial ADP-ribosylation remains poorly understood. Here we provide evidence for mitochondrial ADP-...
Hekman, Ryan M Hume, Adam J Goel, Raghuveera Kumar Abo, Kristine M Huang, Jessie Blum, Benjamin C Werder, Rhiannon B Suder, Ellen L Paul, Indranil Phanse, Sadhna
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Published in
Molecular cell
Brandman, Onn Frost, Adam
Published in
Molecular cell
C-terminal tailing is an ancient and conserved form of peptide synthesis that protects cells from incomplete and potentially toxic translation products. Filbeck et al. (2020) and Crowe-McAuliffe et al. (2020) use structural, genetic, and biochemical approaches to elucidate the mechanisms driving C-terminal tailing. Copyright © 2020 Elsevier Inc. Al...
Silva-Fisher, Jessica Guerrier, Sabrice Nervo, Lathiena Manning Guerra, Amaliris McGill, Lakeya Brooks, Dominique Joseph, Josiane Walker, Marquis Ayombil, Francis Odinammadu, Kamsi
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Published in
Molecular cell
As part of our commitment to amplifying the voices of underrepresented scientists, we are publishing the insights and experiences of a panel of underrepresented scientists in a series of questions and answers. Here, they discuss ways that the scientific community can combat racial inequality and increase diversity. These are the personal opinions o...
Jia, Longfei Qian, Shu-Bing
Published in
Molecular cell
Lamper et al. (2020) reported that eIF3d-mediated cap-dependent translation is subject to regulation by phosphorylation during chronic glucose deprivation, providing a mechanism underlying selective translation of stress genes essential for cell survival. Copyright © 2020 Elsevier Inc. All rights reserved.
Saba, Jason Cao, Xinyun Landick, Robert
Published in
Molecular cell
Travis et al. (2020) reveal how Francisella tularensis uses stress-induced ppGpp to activate its virulent pathogenesis program by tethering an αCTD-DNA organizer (PigR) to a σ-organizing heterodimer (MglA-SspA), highlighting the remarkable diversity of transcriptional mechanisms in under-studied bacteria. Copyright © 2020 Elsevier Inc. All rights r...
Sönmezer, Can Kleinendorst, Rozemarijn Imanci, Dilek Barzaghi, Guido Villacorta, Laura Schübeler, Dirk Benes, Vladimir Molina, Nacho Krebs, Arnaud Regis
Published in
Molecular cell
Gene activation requires the cooperative activity of multiple transcription factors at cis-regulatory elements (CREs). Yet, most transcription factors have short residence time, questioning the requirement of their physical co-occupancy on DNA to achieve cooperativity. Here, we present a DNA footprinting method that detects individual molecular int...
Ziv, Omer Price, Jonathan Shalamova, Lyudmila Kamenova, Tsveta Goodfellow, Ian Weber, Friedemann Miska, Eric A
Published in
Molecular cell
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA genomes in nature, coronaviruses are critically dependent on long-distance RNA-RNA interactions to regulate the viral transcription and replication pathways. Here we experimenta...
Rhine, Kevin Makurath, Monika A. Liu, James Skanchy, Sophie Lopez, Christian Catalan, Kevin F. Ma, Ye Fare, Charlotte M. Shorter, James Ha, Taekjip
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Published in
Molecular cell