Zhang, Shusen Shi, Weidong Chen, Yuyan Xu, Zhiwei Zhu, Jia Zhang, Tingting Huang, Wei Ni, Runzhou Lu, Cuihua Zhang, Xiubing
...
Published in
Molecular and Cellular Biochemistry
SYF2, also known as p29/NTC31/CBPIN, encodes a nuclear protein that interacts with Cyclin D-type binding-protein 1. SYF2 has been reported to be involved in pre-mRNA splicing and cell cycle regulation. In the present study, we observed that SYF2 was obviously upregulated in HCC tumor tissues and cell lines, and its level was positively correlated w...
Litwin, Monika Radwańska, Agata Paprocka, Maria Kieda, Claudine Dobosz, Tadeusz Witkiewicz, Wojciech Baczyńska, Dagmara
Published in
Molecular and Cellular Biochemistry
In recent years, special attention has been paid to finding new pro-angiogenic factors which could be used in gene therapy of vascular diseases such as critical limb ischaemia (CLI). Angiogenesis, the formation of new blood vessels, is a complex process dependent on different cytokines, matrix proteins, growth factors and other pro- or anti-angioge...
Zeng, Xian-Si Jia, Jin-Jing Ma, Li-Fang
Published in
Molecular and Cellular Biochemistry
Oxidative stress plays an important role in many diseases and hydrogen peroxide (H2O2) plays a central role in the stress. Gensenoside Rb1 is the one of active ingredients in the traditional Chinese medicine Panax notoginseng. It has been reported that gensenoside Rb1 possesses various pharmacological activities. Here we report that gensenoside Rb1...
Liu, Minyan Guo, Lei Liu, Yu Pei, Yu Li, Nan Jin, Mengmeng Ma, Lichao Li, Zhibing Sun, Banruo Li, Chunlin
...
Published in
Molecular and Cellular Biochemistry
He, Qiuping Zou, Xifeng Duan, Deyi Liu, Yujun Xu, Qunyuan
Published in
Molecular and Cellular Biochemistry
Normal human embryonic stem cells (hESCs) can develop neoplastic cancer stem cell (CSC) properties after coculture with transformed hESCs in vitro. In the present study, the influence of the tumor microenvironment on malignant transformation of bone marrow stromal cells (BMSCs) was studied after allografting a mixture of enhanced green fluorescent ...
Hamada-Kanazawa, Michiko Ogawa, Daisuke Takano, Masaoki Miyake, Masaharu
Published in
Molecular and Cellular Biochemistry
Sox6 is a transcription factor that induces neuronal differentiation in P19 cells; its suppression not only inhibits neuronal differentiation but also induces retinoic acid (RA)-dependent apoptosis of P19 cells. In the present study, we found that Sox6 suppression-induced apoptosis was mediated by activation of caspase 9 and 3. Moreover, we noted a...
Ranganathan, Santhalakshmi Krishnan, Arunkumar Sivasithambaram, Niranjali Devaraj
Published in
Molecular and Cellular Biochemistry
Twist is a basic helix-loop-helix transcription factor family normally expressed during embryonic development and apparently activated in variety of tumours. Overexpression of twist is correlated with uncontrolled cell proliferation, differentiation, invasion and metastasis. Twist expression is associated with oestrogen receptor (ER); however, the ...
Wagatsuma, Akira Shiozuka, Masataka Takayama, Yuzo Hoshino, Takayuki Mabuchi, Kunihiko Matsuda, Ryoichi
Published in
Molecular and Cellular Biochemistry
Controversy exists as to whether the muscle-specific E3 ubiquitin ligases MAFbx and MuRF1 are transcriptionally upregulated in the process of sarcopenia. In the present study, we investigated the effects of ageing on mRNA/protein expression of muscle-specific E3 ubiquitin ligases and Akt/Foxo signalling in gastrocnemius muscles of female mice. Old ...
Ulker, Esad Parker, William H. Raj, Amita Qu, Zhi-chao May, James M.
Published in
Molecular and Cellular Biochemistry
Vascular endothelial growth factor (VEGF) increases endothelial barrier permeability, an effect that may contribute to macular edema in diabetic retinopathy. Since vitamin C, or ascorbic acid, can tighten the endothelial permeability barrier, we examined whether it could prevent the increase in permeability due to VEGF in human umbilical vein endot...
Tsunoda, Daisuke Iizuka, Haku Ichinose, Tsuyoshi Iizuka, Yoichi Mieda, Tokue Shimokawa, Noriaki Takagishi, Kenji Koibuchi, Noriyuki
Published in
Molecular and Cellular Biochemistry
Congenital scoliosis is a condition characterized by spinal curvature beyond the physiological norm. The molecular mechanisms underlying the pathogenesis of congenital scoliosis are beginning to be clarified; however, the genes related to congenital scoliosis are still unknown. We herein report the results of a comprehensive analysis of gene expres...
