Yang, Xiaosong Wang, Xianfeng Liu, Dongxu Yu, Liqing Xue, Bingzhong Shi, Hang
Published in
Molecular Endocrinology
Adipose tissue macrophages (ATMs) undergo a phenotypic switch from alternatively activated antiinflammatory M2 macrophages in lean individuals to classically activated proinflammatory M1 macrophages in obese subjects. However, the molecular mechanism underlying this process remains unclear. In this study we aim to determine whether DNA methyltransf...
Sriram, Sandhya Subramanian, Subha Juvvuna, Prasanna Kumar Ge, Xiaojia Lokireddy, Sudarsanareddy McFarlane, Craig Desmond Wahli, Walter Kambadur, Ravi Sharma, Mridula
Published in
Molecular endocrinology (Baltimore, Md.)
Smad (Sma and Mad-related protein) 2/3 are downstream signaling molecules for TGF-β and myostatin (Mstn). Recently, Mstn was shown to induce reactive oxygen species (ROS) in skeletal muscle via canonical Smad3, nuclear factor-κB, and TNF-α pathway. However, mice lacking Smad3 display skeletal muscle atrophy due to increased Mstn levels. Hence, our ...
Pitetti, Jean-Luc Calvel, Pierre Zimmermann, Céline Conne, Béatrice Papaioannou, Marilena D Aubry, Florence Cederroth, Christopher R Urner, Françoise Fumel, Betty Crausaz, Michel
...
Published in
Molecular endocrinology (Baltimore, Md.)
Testis size and sperm production are directly correlated to the total number of adult Sertoli cells (SCs). Although the establishment of an adequate number of SCs is crucial for future male fertility, the identification and characterization of the factors regulating SC survival, proliferation, and maturation remain incomplete. To investigate whethe...
Suarez, Philippe Emmanuel Rodriguez, Elena Gonzalez Soundararajan, Rama Mérillat, Anne-Marie Stehle, Jean-Christophe Rotman, Samuel Roger, Thierry Voirol, Marie-Jeanne Wang, Jian Gross, Olaf
...
Published in
Molecular endocrinology (Baltimore, Md.)
The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to generate mice deficient for Tsc22d3-2. Male knockout ...
Conway-Campbell, Becky L George, Charlotte L Pooley, John R Knight, David M Norman, Michael R Hager, Gordon L Lightman, Stafford L
Published in
Molecular endocrinology (Baltimore, Md.)
Glucocorticoid (GC) hormones are secreted from the adrenal gland in a characteristic pulsatile pattern. This ultradian secretory activity exhibits remarkable plasticity, with distinct changes in response to both physiological and stressful stimuli in humans and experimental animals. It is therefore important to understand how the pattern of GC expo...
Moore, Claire E Omikorede, Omotola Gomez, Edith Willars, Gary B Herbert, Terence P
Published in
Molecular endocrinology (Baltimore, Md.)
Protein kinase R-like ER kinase (PERK) is activated at physiologically low glucose concentrations in pancreatic β-cells. However, the molecular mechanisms by which PERK is activated under these conditions and its role in β-cell function are poorly understood. In this report, we investigated, in dispersed rat islets of Langerhans and mouse insulinom...
Széles, Lajos Póliska, Szilárd Nagy, Gergely Szatmari, Istvan Szanto, Attila Pap, Attila Lindstedt, Malin Santegoets, Saskia J A M Rühl, Ralph Dezsö, Balázs
...
Published in
Molecular endocrinology (Baltimore, Md.)
Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (RAR) and vitamin D receptor (VDR), can be activated only by the agonist of the partner receptor. In contrast, heterodimers that contain permissive par...
Menon, Tushar Yates, Joel A Bochar, Daniel A
Published in
Molecular endocrinology (Baltimore, Md.)
The androgen receptor (AR) mediates the effect of androgens through its transcriptional function during both normal prostate development and in the emergence and progression of prostate cancer. AR is known to assemble coactivator complexes at target promoters to facilitate transcriptional activation in response to androgens. Here we identify the AT...
Han, Shuxin Li, Tiangang Ellis, Ewa Strom, Stephen Chiang, John Y L
Published in
Molecular endocrinology (Baltimore, Md.)
Vitamin D receptor (VDR) is activated by natural ligands, 1alpha, 25-dihydroxy-vitamin D(3) [1alpha,25(OH)(2)-D(3)] and lithocholic acid (LCA). Our previous study shows that VDR is expressed in human hepatocytes, and VDR ligands inhibit bile acid synthesis and transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1). Primary human...
Karmakar, Sudipan Gao, Tong Pace, Margaret C Oesterreich, Steffi Smith, Carolyn L
Published in
Molecular endocrinology (Baltimore, Md.)
Although the ability of coactivators to enhance the expression of estrogen receptor-alpha (ERalpha) target genes is well established, the role of corepressors in regulating 17beta-estradiol (E2)-induced gene expression is poorly understood. Previous studies revealed that the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) co...