Liu, Kuancan Xie, Fuan Gao, Anding Zhang, Rui Zhang, Long Xiao, Zhangwu Hu, Qiong Huang, Weifeng Huang, Qiaojia Lin, Baoshun
...
Published in
Molecular Cancer
BackgroundHigh levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood.MethodsIn this study we investigate the role of SOX2 in breast cancer metastasis using multiple in vitro and in vivo assays including cell culture, shRNA-mediated knockdown, wound ...
Wang, Li Zhou, Wei Zhong, Yunfeng Huo, Yongbao Fan, Ping Zhan, Sudong Xiao, Jun Jin, Xin Gou, Shanmiao Yin, Tao
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Published in
Molecular Cancer
BackgroundPancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers. The clinical significance and biological role of GPR87 in pancreatic cancer, however, remain to be established.MethodsGPR87 expression in pancreatic cancer ...
Liu, Wan Li, Jun Song, Yu-Shu Li, Yue Jia, Yu-Hong Zhao, Hai-Dong
Published in
Molecular Cancer
As an atypical member of cyclin dependent kinase family, Cyclin dependent kinase 5 (Cdk5) is considered as a neuron-specific kinase in the past decade due to the abundant existence of its activator p35 in post-mitotic neurons. Recent studies show that Cdk5 participates in a series of biological and pathological processes in non-neuronal cells, and ...
He, Xiaoqing Wang, Liying Riedel, Heimo Wang, Kai Yang, Yong Dinu, Cerasela Zoica Rojanasakul, Yon
Published in
Molecular Cancer
BackgroundLung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of the disease mechanisms. We have identified mesothelin as a potentially unique therapeutic target that as a specific advantage appe...
Zhao, Hua Shen, Jie Hodges, Tiffany R. Song, Renduo Fuller, Gregory N. Heimberger, Amy B.
Published in
Molecular Cancer
Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 primary glioblastoma patients. The s...
Liu, Jing Liu, Tian Wang, Xiaman He, Aili
Published in
Molecular Cancer
A new type of RNAs was identified from genes traditionally thought to express messenger or linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular RNAs) due to the covalently closed structure. Accumulating studies were performed to explore the expression profile of circRNAs in different cell types and diseases, the out...
Mancini, Francesca Teveroni, Emanuela Di Conza, Giusy Monteleone, Valentina Arisi, Ivan Pellegrino, Marsha Buttarelli, Marianna Pieroni, Luisa D’Onofrio, Mara Urbani, Andrea
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Published in
Molecular Cancer
BackgroundMany tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor with oncogenic or anti-survival activities depending on cell growth conditions.MethodMDM4-mTOR relationship was analysed through exp...
Banerjee Mustafi, Soumyajit Chakraborty, Prabir Kumar Dwivedi, Shailendra Kumar Dhar Ding, Kai Moxley, Katherine M. Mukherjee, Priyabrata Bhattacharya, Resham
Published in
Molecular Cancer
BackgroundThe polycomb group protein, BMI1 plays important roles in chromatin modification, stem cell function, DNA damage repair and mitochondrial bioenergetics. Such diverse cellular functions of BMI1 could be, in part, due to post-translational modifications, especially phosphorylation. To date, AKT has been reported as a kinase that by site spe...
Ibrahim, Sherif Abdelaziz Gadalla, Ramy El-Ghonaimy, Eslam A. Samir, Omnia Mohamed, Hossam Taha Hassan, Hebatallah Greve, Burkhard El-Shinawi, Mohamed Mohamed, Mona Mostafa Götte, Martin
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Published in
Molecular Cancer
BackgroundInflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemoki...
Xia, Jianling Wang, Hongqiang Li, Shi Wu, Qinghui Sun, Li Huang, Hongxiang Zeng, Ming
Published in
Molecular Cancer
Gastric cancer (GC) is a common disease with few effective treatment choices and poor prognosis, and has the second-highest mortality rates among all cancers worldwide. Dysregulation and/or malfunction of ion channels or aquaporins (AQPs) are common in various human cancers. Furthermore, ion channels are involved in numerous important aspects of th...
