Zhang, Lei Li, Yidong Hu, Chaohua Chen, Yangmin Chen, Zhuo Chen, Zhe-Sheng Zhang, Jian-Ye Fang, Shuo
Published in
Molecular cancer
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown. Based on single gene knockout, we studied the regulation of CDK6-PI3K axis on ABCB1-mediated MDR in human cancer cells. CRISPR/Cas9 technique was performed ...
Lin, Changwei Ma, Min Zhang, Yi Li, Liang Long, Fei Xie, Canbin Xiao, Hua Liu, Teng Tian, Buning Yang, Kaiyan
...
Published in
Molecular Cancer
Xu, Jiasheng Liao, Kaili Yang, Xi Wu, Chengfeng Wu, Wei
Published in
Molecular Cancer
Li, Xinyi Pu, Wenchen Zheng, Qingquan Ai, Min Chen, Song Peng, Yong
Published in
Molecular Cancer
Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal degradation of target protein by the ubiquitin-proteasome system. PROTAC has emerged as a promising app...
Liu, Ke Cui, Jia-Jia Zhan, Yan Ouyang, Qian-Ying Lu, Qi-Si Yang, Dong-Hua Li, Xiang-Ping Yin, Ji-Ye
Published in
Molecular Cancer
The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to individual differences in the patient TME. Therefore, reprogramming TME cells and their intercellular communication is an attractive and promising ...
Jin, Shufang Li, Mingyu Chang, Hanyue Wang, Ruijie Zhang, Zhiyuan Zhang, Jianjun He, Yue Ma, Hailong
Published in
Molecular cancer
N6-methyladenosine (m6A) RNA modification plays a critical role in various physiological and pathological conditions. However, the role of m6A modification in head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, the expression of m6A demethylases was detected by HNSCC tissue microarray. m6A-RNA immunoprecipitation (MeRIP) s...
Zhai, Wei Li, Saiyang Zhang, Jin Chen, Yonghui Ma, Junjie Kong, Wen Gong, Dongkui Zheng, Junhua Xue, Wei Xu, Yunfei
...
Published in
Molecular Cancer
Yang, Peng Ni, Fang Deng, Rui-Qing Qiang, Guo Zhao, Hua Yang, Ming-Zhen Wang, Xin-Yi Xu, You-Zhi Chen, Li Chen, Dan-Lei
...
Published in
Molecular cancer
Richard, Vinitha Davey, Matthew G. Annuk, Heidi Miller, Nicola Kerin, Michael J.
Published in
Molecular Cancer
Breast cancer continues to be a major global problem with significant mortality associated with advanced stage and metastases at clinical presentation. However, several findings suggest that metastasis is indeed an early occurrence. The standard diagnostic techniques such as invasive core needle biopsy, serological protein marker assays, and non-in...
Wang, Zheng Sun, Anqi Yan, Aihui Yao, Jian Huang, Haibo Gao, Ziming Han, Tao Gu, Jia Li, Ni Wu, Huizhe
...
Published in
Molecular cancer
Circular RNAs (circRNAs) are involved in regulatory processes of ubiquitination and deubiquitination in various tumors at post-transcriptional epigenetic modification level. However, the underlying mechanism and its biological functions of circRNAs in the advanced laryngeal squamous cell carcinoma (LSCC) remain obscure. RNA sequencing and quantitat...
