Serratì, Simona Guida, Michele Di Fonte, Roberta De Summa, Simona Strippoli, Sabino Iacobazzi, Rosa Maria Quarta, Alessandra De Risi, Ivana Guida, Gabriella Paradiso, Angelo
...
Published in
Molecular Cancer
BackgroundThe immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not respond hence, the identification and validation of novel biomarkers of response to ICI is of crucial importance. Circulating extracellular vesicles (EVs) such as PD-L1+ EV ...
Wang, Biyun Zhao, Yannan Li, Yi Xu, Yingying Chen, Yun Jiang, Qiuyu Yao, Dingjin Zhang, Li Hu, Xichun Fu, Chaowei
...
Published in
Molecular Cancer
Yang, Lei Chen, Yi Liu, Ning Lu, Yanwen Ma, Wenliang Yang, Zhenhao Gan, Weidong Li, Dongmei
Published in
Molecular Cancer
BackgroundFunctions of CircMET (hsa_circ_0082002) which is a circular RNA and derived from MET gene remain understood incompletely. In the present study, Xp11.2 translocation/NONO-TFE3 fusion renal cell carcinoma (NONO-TFE3 tRCC) with up-regulated CircMET was employed to investigate its mechanism in cancer progression and post-transcriptional regul...
He, Guangpeng Peng, Xueqiang Wei, Shibo Yang, Shuo Li, Xinyu Huang, Mingyao Tang, Shilei Jin, Hongyuan Liu, Jiaxing Zhang, Sheng
...
Published in
Molecular Cancer
Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective pressure, tumor cells show various adaptive characteristics, such as changes in the expression of cancer hallmarks (increased proliferation, suppressed apoptosis, immune evasion, and so on) and more frequent cell communication. Because of the adaptation of canc...
Du, Jinpeng Lan, Tian Liao, Haotian Feng, Xuping Chen, Xing Liao, Wenwei Hou, Guimin Xu, Lin Feng, Qingbo Xie, Kunlin
...
Published in
Molecular Cancer
BackgroundConsiderable evidence shows that circular RNAs (circRNAs) play an important role in tumor development. However, their function in intrahepatic cholangiocarcinoma (ICC) metastasis and the underlying mechanisms are incompletely understood.MethodscircNFIB (hsa_circ_0086376, termed as cNFIB hereafter) was identified in human ICC tissues throu...
El Fatimy, Rachid Zhang, Yanhong Deforzh, Evgeny Ramadas, Mahalakshmi Saravanan, Harini Wei, Zhiyun Rabinovsky, Rosalia Teplyuk, Nadiya M. Uhlmann, Erik J. Krichevsky, Anna M.
...
Published in
Molecular Cancer
BackgroundmiRNAs are regulatory transcripts established as repressors of mRNA stability and translation that have been functionally implicated in carcinogenesis. miR-10b is one of the key onco-miRs associated with multiple forms of cancer. Malignant gliomas exhibit particularly striking dependence on miR-10b. However, despite the therapeutic potent...
Hosseini, Reza Sarvnaz, Hamzeh Arabpour, Maedeh Ramshe, Samira Molaei Asef-Kabiri, Leila Yousefi, Hassan Akbari, Mohammad Esmaeil Eskandari, Nahid
Published in
Molecular Cancer
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and meta...
Pan, Ziwen Zhao, Rongrong Li, Boyan Qi, Yanhua Qiu, Wei Guo, Qindong Zhang, Shouji Zhao, Shulin Xu, Hao Li, Ming
...
Published in
Molecular Cancer
BackgroundGliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), a newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been shown to play an important role in the pathophysiological...
An, Yuanyuan Duan, Hua
Published in
Molecular Cancer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments. Cancer cells can obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways, which can n...
Wang, Yan Wu, Chunjie Du, Yu Li, Zhongwei Li, Minle Hou, Pingfu Shen, Zhigang Chu, Sufang Zheng, Junnian Bai, Jin
...
Published in
Molecular Cancer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated circRNAs identified through high-throughput RNA sequencing overlapping with polysome profiling indicate that this rule is being broken. CircRN...
