Brooks, Danielle L. Peacock Schwab, Luciana P. Krutilina, Raisa Parke, Deanna N. Sethuraman, Aarti Hoogewijs, David Schörg, Alexandra Gotwald, Lauren Fan, Meiyun Wenger, Roland H.
...
Published in
Molecular Cancer
BackgroundHypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several types of solid tumors, including breast cancers, the HIFs play a critical role in maintaining cancer stem cell (CSC) activity. Thus, we hypothesized that HIFs may also regulate transcri...
Sheng, Xiumei Bowen, Nathan Wang, Zhengxin
Published in
Molecular Cancer
BackgroundGLI pathogenesis-related 1 (GLIPR1) was originally identified in glioblastomas and its expression was also found to be down-regulated in prostate cancer. Functional studies revealed both growth suppression and proapoptotic activities for GLIPR1 in multiple cancer cell lines. GLIPR1’s role in lung cancer has not been investigated. Protein ...
Hanna, Ann Shevde, Lalita A.
Published in
Molecular Cancer
Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extreme and harsh to patients and often have limited success; the danger of cancer is intensified as it metastasizes to secondary locations such ...
Thamkachy, Reshma Kumar, Rohith Rajasekharan, K. N. Sengupta, Suparna
Published in
Molecular Cancer
Backgroundp53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. Prognosis of many tumours also depends upon the p53 status. Most of the clinically used anticancer compounds activate p53 dependent pathway of apoptosis and hence require p53 for thei...
Fan, Tianli Chen, Jing Zhang, Lirong Gao, Pan Hui, Yiran Xu, Peirong Zhang, Xiaqing Liu, Hongtao
Published in
Molecular Cancer
BackgroundThere is growing evidence that Bit1 exerts different roles in the development and progression of human cancers. Although Bit1 was highly exhibited in ESCC tissues in our previous study, its roles and molecular mechanisms implicated in development and progression of ESCC remain unknown.MethodsBit1 protein expression in ESCC cell lines and ...
Yeh, Chien-Hung Bai, Xue Tao Moles, Ramona Ratner, Lee Waldmann, Thomas A. Watanabe, Toshiki Nicot, Christophe
Published in
Molecular Cancer
Wiseman, Elizabeth F. Chen, Xi Han, Namshik Webber, Aaron Ji, Zongling Sharrocks, Andrew D. Ang, Yeng S.
Published in
Molecular Cancer
Pearson, Jodel D. Zhang, Jingxi Wu, Zuoqiao Thew, Kayla D. Rowe, Katelynn J. Bacani, Julinor T. C. Ingham, Robert J.
Published in
Molecular Cancer
Serrano-Gomez, Silvia Juliana Maziveyi, Mazvita Alahari, Suresh K.
Published in
Molecular Cancer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This phenomenon has been well documented in multiple biological processes including embryogenesis, fibrosis, tumor progression and metastasis. The hallmark of EMT is the loss of ep...
Ruan, Jian Zheng, Haiyan Rong, Xiaodong Rong, Xiaomin Zhang, Junyi Fang, Weijia Zhao, Peng Luo, Rongcheng
Published in
Molecular Cancer
BackgroundSeveral studies have found that Cathepsin B (CTSB) is up-regulated in many tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular carcinoma (HCC) progression remains unclear. This study was aimed at investigating the expression and role of CTSB in HCC in a large set of samples and cell lines (MHCC-97H a...
