Wang, Yueqin Wei, Jingyao Feng, Luyao Li, Ouwen Huang, Lan Zhou, Shaoxuan Xu, Yingjie An, Ke Zhang, Yu Chen, Ruiying
...
Published in
Molecular Cancer
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear. Methods The correlation between RNA m5C methylation, m5C writer NOP2/Sun RNA methyltransferase family member 2 (NSUN2) and EGFR-...
Huang, Shengkang Wang, Xinyu Wang, Yu Wang, Yajing Fang, Chenglong Wang, Yazhuo Chen, Sifei Chen, Runkai Lei, Tao Zhang, Yuchen
...
Published in
Molecular Cancer
Chimeric antigen receptor (CAR) T-cell therapy has made remarkable progress in cancer immunotherapy, but several challenges with unclear mechanisms hinder its wide clinical application. Single-cell sequencing technologies, with the powerful unbiased analysis of cellular heterogeneity and molecular patterns at unprecedented resolution, have greatly ...
Krishnan, S. Rajeev Bebawy, M.
Published in
Molecular Cancer
A major obstacle to chemotherapeutic success in cancer treatment is the development of drug resistance. This occurs when a tumour fails to reduce in size after treatment or when there is clinical relapse after an initial positive response to treatment. A unique and serious type of resistance is multidrug resistance (MDR). MDR causes the simultaneou...
Liang, Haihai Zhao, Xiaoguang Wang, Chengyu Sun, Jian Chen, Yingzhun Wang, Guoyuan Fang, Lei Yang, Rui Yu, Mengxue Gu, Yunyan
...
Published in
Molecular Cancer
Li, Tushuai Gu, Yue Xu, Baocai Kuca, Kamil Zhang, Jie Wu, Wenda
Published in
Molecular Cancer
CircZBTB44 (hsa_circ_0002484) has been identified to be upregulated in renal cell carcinoma (RCC) tissues, while its role and contribution in RCC remain elusive. We confirmed the overexpression of circZBTB44 in RCC cells compared to normal kidney cell HK-2. CircZBTB44 knockdown suppressed the viability, proliferation, and migration of RCC cells and...
Shen, Yufei Yang, Wenqing Liu, Jiachen Zhang, Yu
Published in
Molecular Cancer
Su, Boxing Zhao, Wei Shi, Bentao Zhang, Zhongyuan Yu, Xi Xie, Feng Guo, Zhongqiang Zhang, Xiaoyu Liu, Jin Shen, Qi
...
Published in
Molecular Cancer
Tagliamonte, Maria Cavalluzzo, Beatrice Mauriello, Angela Ragone, Concetta Buonaguro, Franco M. Tornesello, Maria Lina Buonaguro, Luigi
Published in
Molecular Cancer
Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response. The vast majority of such strategies are based on tumor associated antigens (TAAs) which are shared wi...
Zhang, Zi-hao Wang, Yue Zhang, Ya Zheng, Sheng-Feng Feng, Tao Tian, Xi Abudurexiti, Mierxiati Wang, Zhen-Da Zhu, Wen-Kai Su, Jia-Qi
...
Published in
Molecular Cancer
Xiong, Li Liu, Hua-Shan Zhou, Chi Yang, Xin Huang, Liang Jie, Hai-Qing Zeng, Zi-Wei Zheng, Xiao-Bin Li, Wen-Xin Liu, Zhan-Zhen
...
Published in
Molecular cancer
Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive. Hypoxia-responsive circular RNAs (circRNAs) were identified by high throughput RNA sequencing between CRC cells cultured und...
