Published in Minerva medica
Endometrial cancer is the most common gynecologic malignancy and in two thirds of patients it is apparently uterine-confined at presentation. Lymph nodal status represents one of the main prognostic factors. Nodal evaluation with SLN mapping has gained more ground in clinical practice after the publication of different studies demonstrating the fea...
Published in Minerva medica
Published in Minerva medica
Cryoglobulinemia is defined by the presence of immunoglobulins having the following characteristics: forming a gel when temperature is
Published in Minerva medica
Hepatitis C virus (HCV) infection affects about 170 million people worldwide. HCV is responsible for both hepatitis and extra-hepatic manifestations. Chronic infection has been shown to develop in about 70% of cases, and it can progress to cirrhosis or hepatocellular carcinoma. Ten percent of HCV patients may develop extra-hepatic manifestations, i...
Published in Minerva medica
Signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in osteoblastic differentiation. However, the exact role of STAT3 in osteogenic differentiation of the pre-osteoblastic cell line MC3T3-E1 is still controversial. In this study, we demonstrated that eradication of STAT3 signaling by the inhibitors cryptotanshinone (CPT,...
Published in Minerva medica
Published in Minerva medica
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene arise in 25-30% of all acute myeloid leukemia (AML) patients. These mutations lead to constitutive activation of the protein product and are divided in two broad types: internal tandem duplication (ITD) of the juxtamembrane domain (25% of cases) and point mutations in the tyrosine kinase domai...
Published in Minerva medica
Baseline cytogenetic/genetic features have been widely recognized to play a critical prognostic role in acute myeloid leukemia (AML) and have proven useful in designing risk-adapted treatment strategies. Nevertheless, to improve further the outcome of AML patients we are still in need of accurate methods to explore the quality of response and to ad...
Published in Minerva medica
Patients with acute lymphoblastic leukemia (ALL) are characterized by an unfavorable outcome in the majority of adult cases. Several clinical trials have confirmed the usefulness of a pediatric-type therapy applied to adult patients. Adults present with higher risk features at diagnosis that predispose them to chemotherapy resistance and disease re...
Published in Minerva medica
