Hilditch, John R Lewis, Jacqueline Peter, Alice van Maris, Barbara Ross, Alan Franssen, Edmée Guyatt, Gordon H Norton, Peter G Dunn, Earl
Published in
Maturitas
To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 menopause symptoms was reduced using the importance score method...
Alraek, Terje Borud, Einar Grimsgaard, Sameline Fønnebø, Vinjar White, Adrian
Published in
Maturitas
Komulainen, Marja H Kröger, Heikki Tuppurainen, Marjo T Heikkinen, Anna-Mari Alhava, Esko Honkanen, Risto Saarikoski, Seppo
Published in
Maturitas
We investigated the incidence of new non-vertebral fractures during HRT or low-dose vitamin (Vit) D3 supplementation in a 5-year prospective trial. A total of 464 early postmenopausal women, (a subgroup of the Kuopio Osteoporosis Study, n = 13100) were randomized to four groups: (1) HRT, a sequential combination of 2 mg estradiol valerate and 1 mg ...
Hunter, Myra Battersby, Rosie Whitehead, Malcolm
Published in
Maturitas
The importance of distinguishing climacteric symptoms from other psychological and somatic complaints has been repeatedly stressed, but as yet no detailed guidelines are available to assist the clinician in the day-to-day management of patients. Previous epidemiological surveys of climacteric symptoms have been criticised because of inadequate meth...
Esmon, Charles T
Published in
Maturitas
Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Multiple mechanisms are at play including up regulation of tissue factor leading to the initiation of clotting, amplification of the clotting process by augmenting exposure of cellular coagulant phospholipids, inhibition of fibrinolysis by elevating plasminogen activator inhibito...
Schindler, Adolf E Campagnoli, Carlo Druckmann, René Huber, Johannes Pasqualini, Jorge R Schweppe, Karl W Thijssen, Jos H H
Published in
Maturitas
Besides the natural progestin, progesterone, there are different classes of progestins, such as retroprogesterone (i.e. dydrogesterone), progesterone derivatives (i.e. medrogestone) 17alpha-hydroxyprogesterone derivatives (i.e. chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, megestrol acetate), 19-norprogesterone derivative...
Sitruk-Ware, Regine
Published in
Maturitas
The synthetic progestins used so far for contraception and menopausal hormone therapy are derived either from testosterone (19-nortestosterone derivatives) or from progesterone (17-OH progesterone derivatives and 19-norprogesterone derivatives). Among the 19-nortestosterone derivatives, the estrane group include norethisterone (NET) and its metabol...
Albertazzi, Paola Purdie, David W
Published in
Maturitas
Non-prescription remedies are becoming increasingly popular particularly amongst postmenopausal who in this market are the largest consumers. Phytoestrogens are a large family of plant derived molecules possessing various degrees oestrogen like activity. Food or food supplements containing phytoestrogen are often been advocated as an alternative to...
Thijssen, Jos H H
Published in
Maturitas
Davis, Susan R McCloud, Philip Strauss, Boyd J G Burger, Henry
Published in
Maturitas
To investigate the role of androgens in increasing bone density and improving low libido in postmenopausal women, we have studied the long-term effects of estradiol and testosterone implants on bone mineral density and sexuality in a prospective, 2 year, single-blind randomised trial. Thirty-four postmenopausal volunteers were randomised to treatme...