Dinnessen, Manette A W van der Poel, Marjolein W M Tonino, Sanne H Visser, Otto Blijlevens, Nicole M A de Jong, Daphne Lam, King H Kersten, Marie José Lugtenburg, Pieternella J Dinmohamed, Avinash G
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Leukemia
We assessed stage-specific trends in primary therapy and relative survival among adult follicular lymphoma (FL) patients diagnosed in the Netherlands between 1989-2016 (N = 12,372; median age, 62 years; and 21% stage I disease). Patients were stratified by disease stage and subsequently categorized into four calendar periods (1989-1995, 1996-2002, ...
Bewersdorf, Jan Philipp Giri, Smith Wang, Rong Podoltsev, Nikolai Williams, Robert T Tallman, Martin S Rampal, Raajit K Zeidan, Amer M Stahl, Maximilian
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Leukemia
Data on the efficacy and safety of interferon (IFN)-α for the treatment of essential thrombocythemia (ET) and polycythemia vera (PV) are inconsistent. We conducted a systematic review and meta-analysis and searched MEDLINE and EMBASE via Ovid, Scopus, COCHRANE registry of clinical trials, and Web of Science from inception through 03/2019 for studie...
Zhang, Cheng Wang, Xiao-Qi Zhang, Rong-Li Liu, Fang Wang, Yi Yan, Zhi-Ling Song, Yong-Ping Yang, Ting Li, Ping Wang, Zhen
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Leukemia
Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects with B-ALL relapsing post allotransplant received CAR-T cells were analyzed. 34 (79%; 95% confidence interval [CI...
Martínez-Cuadrón, David Serrano, Josefina Gil, Cristina Tormo, Mar Martínez-Sánchez, Pilar Pérez-Simón, José A García-Boyero, Raimundo Rodríguez-Medina, Carlos López-Pavía, María Benavente, Celina
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Leukemia
There are no studies analyzing how therapeutic changes impact on outcomes of older AML patients. This study analyzes patient´s and disease characteristics, treatment patterns, and outcomes of 3637 AML patients aged ≥60 years reported to the PETHEMA registry. Study periods were 1999-2006 (before hypomethylating agents-HMAs availability) vs 2007-2013...
Gu, Chunyan Lu, Ting Wang, Wang Shao, Miaomiao Wei, Rongfang Guo, Mengjie Li, Rui Qiao, Li Hu, Ye Zhan, Fenghuang
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Leukemia
Yang, Yong Wang, Ying Liu, Xin He, Xia Zhang, Li-Ling Wu, Gang Qu, Bao-Lin Qian, Li-Ting Hou, Xiao-Rong Zhang, Fu-Quan
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Leukemia
Limited evidence supports the use of early endpoints to evaluate the success of initial treatment of extranodal NK/T-cell lymphoma (ENKTCL) in the modern era. We aim to analyze progression-free survival at 24 months (PFS24) and subsequent overall survival (OS) in a large-scale multicenter cohort of patients. 1790 patients were included from the Chi...
Hasan, Md Kamrul Ghia, Emanuela M Rassenti, Laura Z Widhopf, George F 2nd Kipps, Thomas J
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Leukemia
Patients with chronic lymphocytic leukemia (CLL) have high plasma-levels of Wnt5a, which can induce phosphorylation of ERK1/2 and enhance CLL-cell proliferation. Such effects could be inhibited by treatment with an ERK1/2 inhibitor, ERK1/2-specific siRNA, or cirmtuzumab, an anti-ROR1 mAb. The CLL-derived line, MEC1, expresses Wnt5a, but not ROR1. M...
Arvindam, Upasana Sunil van Hauten, Paulien M M Schirm, Dawn Schaap, Nicolaas Hobo, Willemijn Blazar, Bruce R Vallera, Daniel A Dolstra, Harry Felices, Martin Miller, Jeffrey S
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Leukemia
The low 5-year survival rate for patients with acute myeloid leukemia (AML), primarily caused due to disease relapse, emphasizes the need for better therapeutic strategies. Disease relapse is facilitated by leukemic stem cells (LSCs) that are resistant to standard chemotherapy and promote tumor growth. To target AML blasts and LSCs using natural ki...
de Haas, Valérie Pieters, Rob van der Sluijs-Gelling, Alita J Zwaan, C Michel de Groot-Kruseman, Hester A Sonneveld, Edwin Stigter, Rolinda L van der Velden, Vincent H J
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Leukemia
Gurnari, Carmelo Durrani, Jibran Pagliuca, Simona Kishtagari, Ashwin Awada, Hassan Kerr, Cassandra M Adema, Vera Kongkiatkamon, Sunisa Lichtin, Alan E Patel, Bhumika J
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Leukemia
