Kanabekova, Perizat Dauletkanov, Bereke Bekezhankyzy, Zhibek Toktarkan, Sultanali Martin, Alma Pham, Tri T Kostas, Konstantinos Kulsharova, Gulsim
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Lab on a chip
Here, we report a fluorescent electrospun nanofiber membrane for integration into microfluidic devices towards lung-on-a-chip applications complemented with the results of computational fluid dynamics modelling. A proposed hybrid poly(ε-caprolactone) (PCL)-collagen membrane was developed, characterized, tested, and integrated into a prototype micro...
Wang, Jie Du, Lin Han, Yuwei Zhang, Dawei Jing, Dalei
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Lab on a chip
The utilization of microfluidic analysis technology has resulted in the advancement of fast pathogenic bacteria detection, which can accurately provide information on biochemical reactions in a single cell and enhance detection efficiency. Nevertheless, the achievement of rapid and effective in situ detection of single-bacteria arrays remains a cha...
Yaghoobi, Mohammad Abdelhady, Abdallah Favakeh, Amirhossein Xie, Philip Cheung, Stephanie Mokhtare, Amir Lee, Yoke Lee Nguyen, Ann V Palermo, Gianpiero Rosenwaks, Zev
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Lab on a chip
To understand the impact of sperm speed as they swim against the flow on fertilization rates, we created conditions similar to the female reproductive tract (FRT) on a microfluidic platform for sperm selection. Selected sperm were evaluated based on early development of fertilized embryos. Bovine and human spermatozoa were selected at various fluid...
Shaner, Sebastian Lu, Han Lenz, Maximilian Garg, Shreyash Vlachos, Andreas Asplund, Maria
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Lab on a chip
Electrical stimulation of ex vivo brain tissue slices has been a method used to understand mechanisms imparted by transcranial direct current stimulation (tDCS), but there are significant direct current electric field (dcEF) dosage and electrochemical by-product concerns in conventional experimental setups that may impact translational findings. Th...
McIntyre, David Lashkaripour, Ali Arguijo, Diana Fordyce, Polly Densmore, Douglas
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Lab on a chip
Droplet generation is a fundamental component of droplet microfluidics, compartmentalizing biological or chemical systems within a water-in-oil emulsion. As adoption of droplet microfluidics expands beyond expert labs or integrated devices, quality metrics are needed to contextualize the performance capabilities, improving the reproducibility and e...
Masui, Shuzo Kanno, Yusuke Nisisako, Takasi
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Lab on a chip
Microfluidic post-array devices have the potential to generate quasi-monodisperse emulsion droplets with high throughput and dispersed phase fractions by splitting droplets with regularly arranged posts. However, the lack of understanding of post-array devices makes it challenging to predict droplet size and quantitatively evaluate the influence of...
Dong, Cheng Li, Fei Sun, Yun Long, Dongling Chen, Chunzhao Li, Mengyan Wei, Tao Martins, Rui P Chen, Tianlan Mak, Pui-In
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Lab on a chip
The worldwide COVID-19 pandemic has changed people's lives and the diagnostic landscape. The nucleic acid amplification test (NAT) as the gold standard for SARS-CoV-2 detection has been applied in containing its transmission. However, there remains a lack of an affordable on-site detection system at resource-limited areas. In this study, a low cost...
Illath, Kavitha Kar, Srabani Shinde, Ashwini Ojha, Rajdeep Iyer, Dhanya R Mahapatra, Nitish R Nagai, Moeto Santra, Tuhin Subhra
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Lab on a chip
Photothermal nanoparticle-sensitised photoporation is an emerging approach, which is considered an efficient tool for the intracellular delivery of biomolecules. Nevertheless, using this method to achieve high transfection efficiency generally compromises cell viability and uneven distribution of nanoparticles results in non-uniform delivery. Here,...
Shiri, Farhad Choi, Junseo Vietz, Chad Rathnayaka, Chathurika Manoharan, Anishkumar Shivanka, Suresh Li, Guoqiang Yu, Chengbin Murphy, Michael C Soper, Steven A
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Lab on a chip
While injection molding is becoming the fabrication modality of choice for high-scale production of microfluidic devices, especially those used for in vitro diagnostics, its translation into the growing area of nanofluidics (structures with at least one dimension
Chang, Yu Sheng, Lin Wang, Junjie Deng, Jian Luo, Guangsheng
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Lab on a chip
In recent years, many models have been developed to describe the gas-liquid microdispersion process, which mainly rely on mechanistic analysis and may not be universally applicable. In order to provide a more comprehensive model and, most significantly, to provide a model for design, we have established a general database of microbubble generation ...