Wu, Di Wu, Jianguo Liu, Hui Shi, Shengyu Wang, Liangwen Huang, Yixiao Yu, Xiaorui Lei, Zhuoyue Ouyang, Tanliang Shen, Jia
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Published in
Lab on a chip
Although renal fibrosis can advance chronic kidney disease and progressively lead to end-stage renal failure, no effective anti-fibrotic drugs have been clinically approved. To aid drug development, we developed a biomimetic renal fibrosis progression model on-chip to evaluate anti-fibrotic effects of natural killer cell-derived extracellular vesic...
Yu, Tong Jhita, Navdeep Shankles, Peter Fedanov, Andrew Kramer, Noah Raikar, Sunil S Sulchek, Todd
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Lab on a chip
Genetic reprogramming of immune cells to recognize and target tumor cells offers a possibility of long-term cure. Cell therapies, however, lack simple and affordable manufacturing workflows, especially to genetically edit immune cells to more effectively target cancer cells and avoid immune suppression mechanisms. Microfluidics is a pathway to impr...
Graybill, Philip M Jacobs, Edward J 4th Jana, Aniket Agashe, Atharva Nain, Amrinder S Davalos, Rafael V
Published in
Lab on a chip
Current basement membrane (BM) mimics used for modeling endothelial and epithelial barriers in vitro do not faithfully recapitulate key in vivo physiological properties such as BM thickness, porosity, stiffness, and fibrous composition. Here, we use networks of precisely arranged nanofibers to form ultra-thin (∼3 μm thick) and ultra-porous (∼90%) B...
Wang, Saijie Xu, Quanchen Zhang, Zhihan Chen, Shengbo Jiang, Yizhou Feng, Zhuowei Wang, Dou Jiang, Xingyu
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Lab on a chip
Particle separation plays a critical role in many biochemical analyses. In this article, we report a method of reverse flow enhanced inertia pinched flow fractionation (RF-iPFF) for particle separation. RF-iPFF separates particles by size based on the flow-induced inertial lift, and in the abruptly broadened segment, reverse flow is utilized to fur...
Yadav, Vinit Kumar Ganguly, Preetha Mishra, Prashant Das, Samaresh Mallick, Dhiman
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Lab on a chip
Compartmentalizing magnetically controlled drug molecules is critical in several bioanalytical trials and tests, such as drug screening, digital PCR, magnetic hyperthermia, and controlled magnetic drug targeting (MDT). However, several studies have focused on diluting the nonmagnetic drug using various passive devices based on traditional microfabr...
Zhou, Mengli Ma, Yushu Rock, Edwin C Chiang, Chun-Cheng Luker, Kathryn E Luker, Gary D Chen, Yu-Chih
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Lab on a chip
Cell migration is a complex process that plays a crucial role in normal physiology and pathologies such as cancer, autoimmune diseases, and mental disorders. Conventional cell migration assays face limitations in tracking a large number of individual migrating cells. To address this challenge, we have developed a high-throughput microfluidic cell m...
Huang, Di Zhao, Yekai Fang, Mengjun Shen, Peijie Xu, Hu He, Yichen Chen, Shengfu Si, Zhenjun Xu, Zhinan
Published in
Lab on a chip
The CRISPR Cas system, as a novel nucleic acid detection tool, is often hindered by cumbersome experimental procedures, complicated reagent transfer processes, and associated aerosol pollution risks. In this study, an integrated nucleic acid detection platform named "up and down chip" was developed, which combined RT-RAA technology for nucleic acid...
Huang, Steven H Sartorello, Giovanni Shen, Po-Ting Xu, Chengqi Elemento, Olivier Shvets, Gennady
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Lab on a chip
Correction for 'Metasurface-enhanced infrared spectroscopy in multiwell format for real-time assaying of live cells' by Steven H. Huang et al., Lab Chip, 2023, 23, 2228-2240, https://doi.org/10.1039/d3lc00017f.
Johansson, S. Andreas Dulermo, Thierry Jann, Cosimo Smith, Justin D. Pryszlak, Anna Pignede, Georges Schraivogel, Daniel Colavizza, Didier Desfougères, Thomas Rave, Christophe
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Published in
Lab on a chip
Key to our ability to increase recombinant protein production through secretion is a better understanding of the pathways that interact to translate, process and export mature proteins to the surrounding environment, including the supporting cellular machinery that supplies necessary energy and building blocks. By combining droplet microfluidic scr...
McDuffie, Dennis Alver, Charles G Suthar, Bhumi Helm, Madeline Oliver, David Burgess, R Alan Barr, David Thomas, Emmanuel Agarwal, Ashutosh
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Lab on a chip
Microphysiological Systems (MPSs) or organs-on-chips, are microfluidic devices used to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to its established fabrication methods and biocompatibility properties. However, non-specific binding of small molecules limits PDMS for drug scr...
