Neovascularization in the galactose-fed dog progresses over a period of years, similar to that observed with clinical diabetic retinopathy. The failure of CA-4P to ameliorate neovascularization suggests that chronic, long-term administration may be required to destroy the slowly growing retinal endothelial cells.
Products that provide a higher number of drops per dollar of product offer economic advantages that may not be otherwise discernible by the examination of the product retail price alone. Furthermore, it is shown that altering the angle of administration may, in general, result in significant economic ramifications in the use of multidose artificial...
During the light-dark transition period, resistance to blood flow in the rabbit ophthalmic artery increases in parallel to IOP elevation. The removal of sympathetic activities decreases blood-flow velocity, but increases blood-flow resistance. Like the endogenous elevation of IOP, the time-dependent increase of resistance to blood flow in the rabbi...
The aim of this study was to develop and test a short-term in vitro method for aqueous humour outflow studies using enucleated porcine eyes. The method used was a modification of two methods that have previously been used: whole eyes and anterior segment cultures. The advantage of the model used in this study was that the anterior part of the eye, ...
Topically applied NTX is not only feasible, but also effective over a one hundredfold dosage for accelerating corneal wound healing in diabetic subjects.
Topical treatment with timolol in rabbits can increase the resistance to blood flow in the ophthalmic artery. This effect is caused by a mechanism local to the eye and is not dependent on an IOP change.
The galactose-fed beagle develops diabetes-like microvascular changes that are histologically and clinically similar in appearance to all stages of human diabetic retinopathy. This animal model is extremely useful for evaluating drugs for the treatment of diabetic retinopathy; however, the time required to develop the various retinal lesions (24-72...
These results indicate that ICG is toxic to human RPE cells in culture, and that cell death cannot be attributed to the low osmolarity. Hypothermia of 4 degrees C has a protective effect against ICG toxicity.
These results suggest that 400_g of PVP-I can be tolerated intravitreally in rabbit eyes with no noticeable damage over a 14-day period. Results further showed that 100 microg of intravitreally injected PVP-I has no statistically significant effect on rabbit eyes injected intravitreally with 3030 CFU of S. epidermidis.
A subpressor dose of phentolamine has complex effects on ocular hydrodynamics. The initial IOP decrease is too fast to be explained by aqueous dynamics or ocular rigidity, and so is most likely a result of the disgorgement of choroidal blood volume caused by decreased venous pressure outside the eye. The more prolonged ocular hypotensive effect is ...
