Clarke, Emily Doherty, Daniel Randell, Rebecca Grek, Jonathan Thomas, Rhys Ruddle, Roy A Treanor, Darren
Published in
Journal of clinical pathology
Digital pathology offers the potential for significant benefits in diagnostic pathology, but currently the efficiency of slide viewing is a barrier to adoption. We hypothesised that presenting digital slides for simultaneous viewing of multiple sections of tissue for comparison, as in those with immunohistochemical panels, would allow pathologists ...
Ali, Mahmoud Evans, Harriet Whitney, Peter Minhas, Fayyaz Snead, David R J
Published in
Journal of clinical pathology
The archiving of whole slide images represents a hurdle to digital pathology implementation largely because of the amount of data generated. The retention of glass slides is currently recommended for a minimum of 10 years, but it is for individual departments to determine how digital images are archived and for how long. In a retrospective study, w...
Abid, Muhammad Abbas Ahmed, Sibtain Muneer, Siraj Khan, Samia de Oliveira, Maria Helena Santos Kausar, Rizwana Siddiqui, Imran
Published in
Journal of clinical pathology
This study was done to evaluate the diagnostic accuracy of cerebrospinal fluid kappa free light chain (KFLC) for diagnosis of multiple sclerosis, against isoelectrofocusing (IEF) to detect oligoclonal bands (OCB) as gold standard. 64 cases were divided into positive and negative based on the OCB results. Diagnostic accuracy was calculated for the 1...
Verkouteren, Babette Ja Roemen, Guido Mjm Schuurs-Hoeijmakers, Janneke Hm Abdul Hamid, Myrurgia van Geel, Michel Speel, Ernst-Jan M Mosterd, Klara
Published in
Journal of clinical pathology
Basal cell nevus syndrome (BCNS) is a rare genetic disorder accompanied by a broad variety of tumours, of which basal cell carcinomas and odontogenic keratocysts are the most common. BCNS is caused by a germline or postzygotic mutation in either PTCH1 or SUFU As BCNS is a rare disease, it is difficult to establish whether less frequently occurring ...
Nguyen, Bang Suong Thi Le, Xuan Thao Thi Huynh, Nghia Nguyen, Huy Huu Truong Nguyen, Cong-Minh Nguyen, Bac Hoang
Published in
Journal of clinical pathology
The aim of this study was to determine common variants in F8, including intron 22 inversion (Inv22), intron 1 inversion (Inv1) and point mutations, the transmission of these variants between patients with haemophilia A (HA) and their family members. Genetic analysis was conducted in 71 patients who were clinically diagnosed with HA and 152 related ...
Pang, Jiuhong Xia, Hongai Mi, Shijun Zhang, Wen Pendrick, Danielle Freeman, Christopher Fernandes, Helen Mansukhani, Mahesh Hsiao, Susan J
Published in
Journal of clinical pathology
Tumour mutational burden (TMB) is used to predict response to immunotherapies. Although several groups have proposed calculation methods for TMB, a clear consensus has not yet emerged. In this study, we explored TMB calculation approaches with a 586-gene cancer panel (1.75 Mb) benchmarked to TMB measured by whole-exome sequencing (WES), using 30 sa...
Martín-Román, Lorena Lozano, Pablo Gómez, Yesica Fernández-Aceñero, María Jesús Vasquez, Wenceslao Palencia, Natividad González-Bayón, Luis
Published in
Journal of clinical pathology
Several classification systems are used for pseudomyxoma peritonei. The four-tiered classification system proposed by Peritoneal Surface Oncology Group International (PSOGI) and the two-tiered proposed by the eighth edition of the American Joint Committee on Cancer (AJCC) result from evolution in terminology and pathological insight. The aim is to ...
Elghobashy, Mirna Wahab, Lutful Gunavardhan, Anu O'Sullivan, Emma Provenzano, Elena Deb, Rahul Pritchard, Susan Di Palma, Silvana Ellis, Ian O Boyd, Clinton
...
Published in
Journal of clinical pathology
There is little information on the impact of COVID-19 on breast pathologists. This survey assessed the effect of the COVID-19 pandemic on UK and Ireland-based breast pathologists to optimise working environments and ensure preparedness for potential future pandemics. A 35-question survey during the first wave of COVID-19 infections in the UK includ...
Humphris, Katherine Stephenson, John Kumaraswamy, Vidya
Published in
Journal of clinical pathology
Oncotype DX testing is a reliable widely used gene assay to determine whether chemotherapy is of additional value in oestrogen receptor (ER) positive Human Epidermal Growth Factor receptor 2 (HER2) negative, node negative breast cancer, but the high cost of the test can be a barrier for optimal therapy guidance for a substantial proportion of eligi...
Mullane, Patrick Joshi, Shreyas Bilen, Mehmet Osunkoya, Adeboye O
Published in
Journal of clinical pathology
A subset of patients with urothelial carcinoma (UCa) and lamina propria (LP) invasion in bladder biopsies/transurethral resections (TURs) are at significant risk for recurrence and have increased rates of progression to UCa with muscularis propria (MP) invasion. The clinicopathologic features of this patient population has not been well characteris...
