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Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer.

Published in Journal of clinical pathology

The mechanisms that drive breast cancer (BC) progression and poor outcome are not fully understood. The human heat shock protein 90 alpha family class A member 1 (HSP90α) encoded by the HSP90ΑA1 gene has a vital role in cellular responses to stress and is implicated in the development and progression of many cancers. The current study aims to explo...

Performance evaluation of the Biocartis Idylla EGFR Mutation Test using pre-extracted DNA from a cohort of highly charac...

Published in Journal of clinical pathology

Targeted therapies for non-small cell lung carcinoma (NSCLC) rely on the detection of specific genomic lesions, such as mutations within the epidermal growth factor receptor (EGFR) gene. The Biocartis Idylla platform and single-use EGFR mutation test cartridge is CE-IVD for use with formalin-fixed paraffin embedded (FFPE) tumour material, but can a...

Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patien...

Published in Journal of clinical pathology

The role of specific blood tests to predict poor prognosis in patients admitted with infection from SARS-CoV-2 remains uncertain. During the first wave of the global pandemic, an extended laboratory testing panel was integrated into the local pathway to guide triage and healthcare resource utilisation for emergency admissions. We conducted a retros...

Prevalence and breakdown of EGFR exon 20 driver mutations in routine NHS lung cancer diagnostic testing.

Published in Journal of clinical pathology

Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeir...

Published in Journal of clinical pathology

This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data. A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnai...

Persistent viral infectivity after 27 days from COVID-19 symptoms onset.

Published in Journal of clinical pathology

Diagnostic utility of droplet digital PCR to detect TERT promoter mutations among glioblastoma samples using 7-deaza-dGT...

Published in Journal of clinical pathology

When dirt is not dirt! Duncan's dirty dermatosis put under the microscope.

Published in Journal of clinical pathology

Tissue methylation and demethylation influence translesion synthesis DNA polymerases (TLS) contributing to the genesis o...

Published in Journal of clinical pathology

DNA methylation has its distribution influenced by DNA demethylation processes with the catalytic conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Myelodysplastic syndrome (MDS) has been associated with epigenetic dysregulation of genes related to DNA repair system, chronic immune response and cell cycle. We evaluated the t...

Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients.

Published in Journal of clinical pathology

The number of clinical autopsies decreases while the rate of missed relevant diagnoses is known to be 2%-20%. In this study, we focused on postmortem examinations of patients after transplantation of solid organs. A total of 122 cases were assessed for this study. Transplant organs included liver (LiTx; n=42/122, 34%), heart (n=8/122, 7%), lungs (n...