Kobidze, Giorgi Sprega, Giorgia Daziani, Gloria Balloni, Aurora Lo Faro, Alfredo Fabrizio Farkas, Tivadar Peluso, Paola Basile, Giuseppe Busardò, Francesco Paolo Chankvetadze, Bezhan
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Published in
Journal of chromatography. A
The different behavior of enantiomers of chiral compounds in non-isotropic environments (among them in living organism) is well known. On the other hand, the importance of a kinetic isotope effect in the biomedical field has become evident during past few decades. Thus, separation of both, enantiomers and isotopologues is now critical. Only very fe...
Altern, Scott H Kocot, Andrew J LeBarre, Jacob P Boi, Cristiana Phillips, Michael W Roush, David J Menegatti, Stefano Cramer, Steven M
Published in
Journal of chromatography. A
Although antibody fragments are a critical impurity to remove from process streams, few platformable purification techniques have been developed to this end. In this work, a novel size-exclusion-mixed-mode (SEMM) resin was characterized with respect to its efficacy in mAb fragment removal. Inverse size-exclusion chromatography showed that the silic...
Liang, Haizhen Yuan, Shuo Ma, Xiaoli Song, Qingqing Song, Yuelin Tu, Pengfei Jiang, Yong
Published in
Journal of chromatography. A
Murrayae Folium et Cacumen (MFC) is a traditional Chinese medicine (TCM) derived from two plant species, Murraya exotica L. and Murraya paniculata (L.) Jack, as recorded in the Chinese Pharmacopoeia. However, there is no research available on the comprehensive analysis and comparison of the chemical constituents of these two species. In the present...
Mlinarić, Zvonimir Turković, Lu Sertić, Miranda
Published in
Journal of chromatography. A
Herein, we have developed a novel method of aqueous-sample dispersive liquid-liquid microextraction (AqS-DLLME) followed by sweeping micellar electrokinetic chromatography-tandem mass spectrometry (MEKC-MS/MS) for simultaneous determination of breast cancer drugs letrozole, anastrozole, palbociclib, ribociclib, abemaciclib, and fulvestrant in human...
Rajska, Anna Raczak-Gutknecht, Joanna Struck-Lewicka, Wiktoria Buszewska-Forajta, Magdalena Wityk, Paweł Verding, Phaedra Kowalewska, Agnieszka Siluk, Danuta Rachoń, Dominik Jan Markuszewski, Michał
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Published in
Journal of chromatography. A
Hyperandrogenism is one of the most pronounced symptoms of Polycystic Ovary Syndrome (PCOS) and seems to play a key role in the pathogenesis of this complex disorder. Nevertheless, there is still a lack of consistent results regarding common steroid predictors of PCOS. Therefore, a liquid chromatography tandem mass spectrometry (HPLC-QqQ/MS) method...
Song, James Y Farkas, Tivadar
Published in
Journal of chromatography. A
Adeno-associated virus (AAV) analytical characterization is crucial to the well-defined and reproducible production of human gene therapies utilizing the AAV vector modality. The establishment of analytical methods based upon technology platforms currently widely used by bio-therapeutic manufacturers, namely HPLC, will assist efforts to produce hig...
Wang, Luchun Liu, Qiuyi Zou, Yuemeng Liu, Shaochi Yang, Yulian Tao, Yongqing Wang, Mingyue Li, Lingling Wang, Dandan Gao, Die
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Published in
Journal of chromatography. A
A magnetic molecular imprinted covalent organic framework composite (MCOF-MIP) that possessed the 'dual-selectivity' of a covalent organic framework and molecular imprinted polymer (MIP) with rapid response performance was successfully prepared for the removal of bisphenol AF (BPAF) from real water and blood samples. First, the MCOF was separately ...
Jiao, Heping Bi, Ruixiang Li, Fangli Chao, Jingbo Zhang, Guimin Zhai, Lihai Hu, Ligang Wang, Zhenhua Dai, Caifeng Li, Bing
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Published in
Journal of chromatography. A
The complex and cumbersome preparation of magnetic covalent organic frameworks (COFs) nanocomposites on a small scale limits their application. Herein, a rapid and easy route was employed for the preparation of magnetic thiourea-based COFs nanocomposites. COFs were coated on Fe3O4 nanoparticles at room temperature without a catalyst within approxim...
Prakasham, Karthikeyan Pan, Tzu-Yu Tan, Chun-Hsiang Wu, Chia-Fang Chandra, Pranjal Cheng, Ching-Mei Chen, Wei Tsai, Wei-Chung Ponnusamy, Vinoth Kumar Wu, Ming-Tsang
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Published in
Journal of chromatography. A
Apixaban and dabigatran are the two major direct oral anticoagulant drugs to treat thromboembolic disordered patients. Increasing the clinical application for the thromboembolic disorder and monitoring the concentrations of apixaban, dabigatran, and their metabolites are essential in most clinical circumstances. In this work, we developed a rapid a...
Fan, Yu Sun, Yan-Na Qiao, Liang-Zhi Mao, Ruo-Que Tang, Si-Yuan Shi, Ce Yao, Shan-Jing Lin, Dong-Qiang
Published in
Journal of chromatography. A
Multi-column periodic counter-current chromatography is a promising technology for continuous antibody capture. However, dynamic changes due to disturbances and drifts pose some potential risks for continuous processes during long-term operation. In this study, a model-based approach was used to describe the changes in breakthrough curves with feed...
