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Modified graphene-silica as a sorbent for in-tube solid-phase microextraction coupled to liquid chromatography-tandem ma...

Published in Journal of chromatography. A

Given the increasing need for analyzing natural or contaminating compounds in complex food matrices in a simple and automated way, coupling miniaturized sample preparation techniques with chromatographic systems have become a growing field of research. In this regard, given the low extraction efficiency of conventional sorbent phases, the developme...

Pushing the limits of resolving power and analysis time in on-line comprehensive hydrophilic interaction x reversed phas...

Published in Journal of chromatography. A

In the present work, we have investigated the combination of hydrophilic interaction liquid chromatography (HILIC) and reversed phase liquid chromatography (RPLC) for the separation of peptides in on-line HILIC x RPLC. This combination usually leads to significant solvent strength mismatch, since a weak solvent in HILIC becomes a strong solvent in ...

Enantiomeric separation of ivabradine by cyclodextrin-electrokinetic chromatography. Effect of amino acid chiral ionic l...

Published in Journal of chromatography. A

A chiral methodology was developed for the first time to ensure the quality control of ivabradine, a novel anti-ischemic and heart rate lowering drug commercialized as a pure enantiomer. With this aim, electrokinetic chromatography (EKC) was employed and the enantiomeric separation of ivabradine was investigated using different anionic and neutral ...

Mismatch between sample diluent and eluent: Maintaining integrity of gradient peaks using in silico approaches.

Published in Journal of chromatography. A

The mismatch of elution strength between the sample diluent and the eluent causes undesirable peak deformations for large sample volumes in gradient liquid chromatography. The solution to that problem consists in diluting the sample solution in a weak solvent. But the minimum dilution factor has to be determined by the user given some performance o...

Electromembrane extraction of aristolochic acids: New insights in separation of bioactive ingredients of traditional Chi...

Published in Journal of chromatography. A

Aristolochic acid (AA) I and AA II, which have been classified as carcinogenic to human and have been proven to be nephrotoxic, are bioactive ingredients of many traditional Chinese medicines (TCMs). Thus, development of an efficient approach for separation and determination of AA I and AA II in biological samples and herbal plants is of significan...

Rapid simultaneous determination of 160 drugs in urine and blood of livestock and poultry by ultra-high-performance liqu...

Published in Journal of chromatography. A

In order to address the specific question of food safety in livestock and poultry, it is imperative to monitor veterinary drugs at every moment in the process of livestock and poultry breeding. Thus, multi-residue analysis of a wide variety of drugs using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has become...

Preparation of magnetite/multiwalled carbon nanotubes/metal-organic framework composite for dispersive magnetic micro so...

Published in Journal of chromatography. A

In the current study, [email protected](Cr) (Fe3O4/multiwalled carbon nanotubes/MIL-101(Cr)) was synthesized and utilized as a new sorbent for the first time. It was employed successfully for the extraction of parabens and phthalate esters (PEs) from water and cream samples prior to their quantification with HPLC-DAD. The prepared metal-organic-frame...

Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome.

Published in Journal of chromatography. A

The characterization of metabolome for poorly absorptive natural medicines is challenging. Previous identification strategy often relies on nontargeted scanning biological samples from animals administered with natural medicines in a data-dependent acquisition (DDA) mode by LC-MS/MS. Substances that displayed significant increases following drug ad...

Traditional medicine 2019.

Published in Journal of chromatography. A

Amino acid chiral ionic liquids combined with hydroxypropyl-β-cyclodextrin for drug enantioseparation by capillary elect...

Published in Journal of chromatography. A

Four amino acid chiral ionic liquids were evaluated in dual systems with hydroxypropyl-β-cyclodextrin to investigate the enantioseparation by CE of a group of seven drugs as model compounds (duloxetine, verapamil, terbutaline, econazole, sulconazole, metoprolol, and nadolol). The use of two of these chiral ionic liquids (tetramethylammonium L-Lysin...