Tummarello, D Guidi, F Di Furia, L Gramazio, A Menichetti, E Cellerino, R
Published in
Journal of chemotherapy (Florence, Italy)
Sixteen patients with advanced small cell lung cancer who relapsed or progressed under first-line therapy, were treated with second-line chemotherapy consisting of: teniposide, 60 mg/m2, i.v. days 1-5, every 3 weeks until further progression. The response rate was: 3 minor responses, 6 stable disease, 5 progressive disease, 1 early death and 1 not ...
Donno, L
Published in
Journal of chemotherapy (Florence, Italy)
The knowledge of the plasmodium life-cycle is essential for the use of antimalarial drugs and their combinations. The antimalarial drugs currently available can act on one or more stages of parasitic development, but only on its proliferative phases. The combinations of drugs in the treatment of malaria aim at three distinct objectives: a) action o...
Bergan, T
Published in
Journal of chemotherapy (Florence, Italy)
The third generation quinolones, ciprofloxacin, enoxacin, fleroxacin, norfloxacin, ofloxacin and pefloxacin are all quickly and quantitatively well (75-95% of an oral dose) absorbed upon oral administration. The maximum serum concentrations appear after 1-2 hours. The serum and urine concentrations after oral or intravenous ciprofloxacin are direct...
Amichetti, M Valentini, A
Published in
Journal of chemotherapy (Florence, Italy)
Forty-five patients with epidermoid cancer of the head and neck were either treated with cisplatin and bleomycin (DDP-BLM) or with vincristine, bleomycin and methotrexate (VBM) as neoadjuvant chemotherapy before radical radiation therapy (XRT). Chemotherapy with DDP-BLM provided a tumoral response of 80% [20% complete response (CR), 60% partial res...
Nord, C E Edlund, C
Published in
Journal of chemotherapy (Florence, Italy)
This review article summarizes the published data concerning the impact of ciprofloxacin and norfloxacin on the oropharyngeal and intestinal human microflora. The use of ciprofloxacin and norfloxacin for selective decontamination in compromised patients and for prophylaxis of recurrent urinary tract infections is also reviewed.
Garozzo, A Rossi, M Denaro, A Allegra, E Santangelo, G Amato, M Tomasello, C
Published in
Journal of chemotherapy (Florence, Italy)
A new method to test the sensitivity of human tumor cells has been developed. A suspension of mechanically dissociated tumor cells is kept in continuous incubation for 24h, in cultures with antineoplastic agents. Drug induced cell cycle perturbations are monitored by flow cytometric computer analysis and DNA distributions of the cells stained with ...
Periti, P Mini, E
Published in
Journal of chemotherapy (Florence, Italy)
The primary cause of failure of the pharmacological treatment of cancer is the occurrence of intrinsic or acquired resistance to drugs in tumor cells. Drug resistance occurs through a variety of mechanisms and usually results from mutation or amplification of genes. Biochemical and genetic mechanisms by which tumor cells may become resistant clinic...
Thadepalli, H Mathai, D Chuah, S K Bansal, M B
Published in
Journal of chemotherapy (Florence, Italy)
Intravenous ciprofloxacin therapy was evaluated in comparison with i.v. ceftazidime in the treatment of skin and soft tissue infections and were found to be comparable. Intravenous or peroral forms of ciprofloxacin may be used instead of intravenously given third generation cephalosporins or aminoglycosides in the treatment of even severe infection...
Piens, M A Garin, J P
Published in
Journal of chemotherapy (Florence, Italy)
The usual chemoprophylaxis of toxoplasmosis consists of spiramycin or the combination of pyremethamine-sulfamide. This chemoprophylaxis can be used: 1 - In the pregnant woman: spiramycin avoids or has low fetal damage. In case of maternal contamination after 33 weeks of pregnancy, pyrimethamine-sulfadiazine combination should be used in spite of it...
Casal, M Rodríguez, F Gutierrez, J Ruiz, P Benavente, M C Villalba, R Moreno, G
Published in
Journal of chemotherapy (Florence, Italy)
The aims of this work were to investigate the possible effect of several antimicrobial agents alone and in combinations against 190 clinical isolates of Mycobacterium tuberculosis and 30 isolates of Mycobacterium avium, 30 Mycobacterium fortuitum and 30 Mycobacterium chelonei. The susceptibility was determined in Müller-Hinton agar and Middlebrook ...
