Shahriari, Shadi Ghildyal, Reena
Published in
Journal of Virology
Respiratory syncytial virus is responsible for severe lower respiratory tract infections in young children under 5 years old, the elderly, and the immunosuppressed. The interaction of the respiratory syncytial virus matrix protein with the host actin cytoskeleton is important in infection but has not been investigated in depth. In this study, we sh...
Do, Thi H. T. Wille, Michelle Wheatley, Adam K. Koutsakos, Marios
Published in
Journal of Virology
Influenza B viruses (IBVs) contribute to annual epidemics and may cause severe disease, especially in children. Consequently, several approaches are being explored to improve vaccine efficacy, including the addition of neuraminidase (NA). Antigen selection and assessment of serological responses will require a reliable serological assay to specific...
Haas, Griffin D. Kowdle, Shreyas Schmitz, Katharina S. Azarm, Kristopher D. Johnson, Kendra N. Klain, William R. Freiberg, Alexander N. Cox, Robert M. Plemper, Richard K. Lee, Benhur
...
Published in
Journal of Virology
Henipaviruses are recognized as significant global health threats due to their high mortality rates and lack of effective vaccines or therapeutics. Due to the requirement for high biocontainment facilities, the scope of research which may be conducted on henipaviruses is limited. To address this challenge, we developed innovative tetracistronic, tr...
Shen, Mingyue Sun, Zhenhong Wang, Cheng Zhang, Shuyu Jia, Baoyu Huang, Bohan Xu, Li Zhu, Zhiyu Bu, Qingyun Li, Chen
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Published in
Journal of Virology
Although duck circovirus (DuCV) poses a widespread infection and a serious hazard to the duck industry, the molecular mechanisms underlying DuCV infection and transmission remain elusive. We initially demonstrated vertical transmission of DuCV through female breeding ducks by simulating natural infection. Furthermore, a differentially expressed mem...
Quellec, Jordan Piro-Megy, Camille Cannac, Marion Nisole, Sébastien Marty, Florent H. Gosselet, Fabien Shimizu, Fumitaka Kanda, Takashi Cêtre-Sossah, Catherine Salinas, Sara
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Published in
Journal of Virology
The RVF virus (RVFV) is capable of infecting humans and inducing severe and fatal neurological disorders. Neuropathogenesis and human central nervous system (CNS) invasion mechanisms of RVFV are still unknown, with only historical studies of autopsy data from fatal human cases in the 1980s and exploration studies in rodent models. One of the gaps i...
Kang, Joon S. Zhou, Kang Wang, Hui Tang, Sijia Lyles, Kristin Van Mouwerik Luo, Ming Zhou, Z. Hong
Published in
Journal of Virology
The impact of COVID-19 on public health has highlighted the importance of understanding zoonotic pathogens. Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne human pathogen that causes hemorrhagic fever. Herein, we describe the in situ structure of LCMV proteins and their architectural organization on the viral envelope and around the nuc...
Yang, Yan Li, Xuehui Su, Dan
Published in
Journal of Virology
Lv, Bonan Yuan, Yuncong Yang, Zhuang Wang, Xingran Hu, Jianjun Sun, Yidan Du, Hang Liu, Xuemei Duan, Huimin Ding, Ruyi
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Published in
Journal of Virology
Many positive-stranded RNA viruses, including foot-and-mouth disease virus (FMDV), alter host membranes and lipid metabolism to create a suitable microenvironment for their survival and replication within host cells. In FMDV-infected cells, the endoplasmic reticulum membrane is remodeled, forming vesicular structures that rely heavily on increased ...
Gallichotte, Emily N. Fitzmeyer, Emily A. Williams, Landon Spangler, Mark Cole Bosco-Lauth, Angela M. Ebel, Gregory D.
Published in
Journal of Virology
West Nile virus (WNV) and St. Louis encephalitis virus (SLEV) are closely related viruses that are transmitted by the same mosquitoes and infect the same birds in nature. Both viruses circulate in the same regions and have caused concurrent outbreaks in humans. It is possible that mosquitoes, birds, and/or humans could be infected with both WNV and...
Hamele, Cait E. Luo, Zhaochen Leonard, Rebecca A. Spurrier, M. Ariel Burke, Kaitlyn N. Webb, Stacy R. Rountree, Wes Li, Zongli Heaton, Brook E. Heaton, Nicholas S.
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Published in
Journal of Virology
Current seasonal influenza vaccines provide incomplete protection from disease. This is partially the result of the antibody response being directed toward parts of the virus that are tolerant of mutations. Redirecting the immune response to more conserved regions of the virus has been a central strategy of next-generation vaccine designs and appro...