Chen, Si Liang, Bowei Xu, Jianyong
Published in
Journal of Translational Medicine
Mesenchymal stem/stromal cells (MSCs) represent a heterogeneous cell population distributed throughout various tissues, demonstrating remarkable adaptability to microenvironmental cues and holding immense promise for disease treatment. However, the inherent diversity within MSCs often leads to variability in therapeutic outcomes, posing challenges ...
Ma, Ruijue Li, Yingxi Dong, Xiaoli Zhang, Yiming Chen, Xiaosu Zhang, Yue Zou, Haohan Wang, Yan
Published in
Journal of Translational Medicine
Background Corneal injuries, often leading to severe vision loss or blindness, have traditionally been treated with the belief that limbal stem cells (LSCs) are essential for repair and homeostasis, while central corneal epithelial cells (CCECs) were thought incapable of such repair. However, our research reveals that CCECs can fully heal and maint...
Falco, Antonia Basile, Anna Raimondo, Annunziata Guglielmi, Giulia Rosati, Alessandra De Marco, Margot Turco, Maria Caterina Pascale, Maria Lembo, Serena
Published in
Journal of Translational Medicine
Yu, Shao-Kun Yu, Tao Wang, Yu-Ming Sun, Ao Liu, Jia Lu, Kai-Hua
Published in
Journal of Translational Medicine
Background Chaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized proteins. However, its roles and underlying mechanisms in lung adenocarcinoma (LUAD), one of the most aggressive cancers, remain elusive. Methods Our study utilized in vitro cell phenotype experiments to as...
Liu, Nannan Fan, Xuefei Shao, Yubao Chen, Suhuan Wang, Taorong Yao, Tao Chen, Xiaoyu
Published in
Journal of Translational Medicine
Background and purpose Interstitial lung disease (ILD) represents a significant complication of rheumatoid arthritis (RA) that lacks effective treatment options. This study aimed to investigate the intrinsic mechanism by which resveratrol attenuates rheumatoid arthritis complicated with interstitial lung disease through the AKT/TMEM175 pathway. Met...
Pongracz, Tamas Biewenga, Maaike Stoelinga, Anna Eva Charlotte Bladergroen, Marco René Nicolardi, Simone Trouw, Leendert Adrianus Wuhrer, Manfred de Haan, Noortje van Hoek, Bart
Published in
Journal of Translational Medicine
Background Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis and hepatocellular carcinoma. Autoimmune hepatitis (AIH) is a liver disease characterized by liver inflammation and raised serum levels of IgG, and is difficult to distinguish from other liver diseas...
Rahmati, Soheil Moeinafshar, Aysan Rezaei, Nima
Published in
Journal of Translational Medicine
Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell–cell communication. Colorectal cancer (CRC) is one of the most common cancers worldwide, with metastasis being the leading cause of mortalit...
Du, Jixiang Liu, Fuchen Liu, Xihan Zhao, Dandan Wang, Dongdong Sun, Hongsheng Yan, Chuanzhu Zhao, Yuying
Published in
Journal of Translational Medicine
Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP , leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). However, the impact of TP deficiency on lysosomes remains unclear, which are important for mitochondrial quality control and nucleic aci...
Kim, Baek Gil Lee, Sung Hwan Jang, Yeonsue Kang, Suki Kang, Chang Moo Cho, Nam Hoon
Published in
Journal of Translational Medicine
Background The lack of distinct biomarkers for pancreatic cancer is a major cause of early-stage detection difficulty. The pancreatic cancer patient group with high metabolic tumor volume (MTV), one of the values measured from positron emission tomography—a confirmatory method and standard care for pancreatic cancer, showed a poorer prognosis than ...
Huang, Mingtao Zhang, Qinxin Jiao, Jiao Shi, Jianquan Xu, Yiyun Zhang, Cuiping Zhou, Ran Liu, Wenwen Liang, Yixuan Chen, Hao
...
Published in
Journal of Translational Medicine
Background Facioscapulohumeral muscular dystrophy (FSHD) is a high-prevalence autosomal dominant neuromuscular disease characterized by significant clinical and genetic heterogeneity. Genetic diagnosis of FSHD remains a challenge because it cannot be detected by standard sequencing methods and requires a complex diagnosis workflow. Methods We devel...