Wang, Yi Deng, Hui Pan, Yihuai Jin, Lijian Hu, Rongdang Lu, Yongyong Deng, Wenhai Sun, Weijian Chen, Chengshui Shen, Xian
...
Published in
Journal of Translational Medicine
BackgroundEmerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.MethodsSummary statis...
Na, Hee Young Park, Yujun Nam, Soo Kyung Koh, Jiwon Kwak, Yoonjin Ahn, Sang-Hoon Park, Do Joong Kim, Hyung-Ho Lee, Kyu Sang Lee, Hye Seung
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Published in
Journal of Translational Medicine
BackgroundNatural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface receptors in gastric cancer (GC) by using multiplex immunohistochemistry (mIHC).MethodsWe performed a...
Mauriello, Angela Cavalluzzo, Beatrice Manolio, Carmen Ragone, Concetta Luciano, Antonio Barbieri, Antonio Tornesello, Maria Lina Buonaguro, Franco M. Tagliamonte, Maria Buonaguro, Luigi
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Published in
Journal of Translational Medicine
The host’s immune system may be primed against antigens during the lifetime (e.g. microorganisms antigens—MoAs), and swiftly recalled upon growth of a tumor expressing antigens similar in sequence and structure. C57BL/6 mice were immunized in a preventive setting with tumor antigens (TuAs) or corresponding heteroclitic peptides specific for TC-1 an...
Wang, Yi Deng, Hui Pan, Yihuai Jin, Lijian Hu, Rongdang Lu, Yongyong Deng, Wenhai Sun, Weijian Chen, Chengshui Shen, Xian
...
Published in
Journal of Translational Medicine
BackgroundEmerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.MethodsSummary statis...
Han, YaGuang Wu, Jun Gong, ZhenYu Zhou, YiQin Li, HaoBo Wang, Bo Qian, QiRong
Published in
Journal of Translational Medicine
BackgroundOsteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers for the prevention, diagnosis, and treatment of OA.Methods and materialsThe GSE129147, GSE57218, GSE51588, GSE117999, and GSE98918 ...
Creisméas, Anna Gazaille, Claire Bourdon, Audrey Lallemand, Marc-Antoine François, Virginie Allais, Marine Ledevin, Mireille Larcher, Thibaut Toumaniantz, Gilles Lafoux, Aude
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Published in
Journal of Translational Medicine
BackgroundDuchenne muscular dystrophy (DMD) is an X-linked inherited disease caused by mutations in the gene encoding dystrophin that leads to a severe and ultimately life limiting muscle-wasting condition. Recombinant adeno-associated vector (rAAV)-based gene therapy is promising, but the size of the full-length dystrophin cDNA exceeds the packagi...
Yihan, Liu Xiaojing, Wang Ao, Liu Chuanjie, Zhang Haofei, Wang Yan, Shen Hongchao, He
Published in
Journal of Translational Medicine
BackgroundThe aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC).MethodsSIRT5 expression data in The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) were selected, and the correlations between SIRT5 expression and various clinicopathological paramet...
Wang, Huai-yu Meng, Qinqin Yang, Chao Wang, Yafeng Kong, Guilan Zhao, Yaohui Wang, Fang Zhang, Luxia
Published in
Journal of Translational Medicine
BackgroundAssociation between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.MethodsParticipants aged ≥ 45 years, with complete data in 2011 and 2015 interviews of the China Health and Retirement Longitudinal Study(CHARLS), and without pre-existing hypertension were incl...
Chouchane, Karim Di Zenzo, Giovanni Pitocco, Dario Calabrese, Laura De Simone, Clara
Published in
Journal of Translational Medicine
Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain drugs’ exposures. Since 2011, a growing number of observations has been reporting cases of BP in Type 2 diabetic patients. These forms have ...
Zhang, Jia-Yi Zhu, Wei-Wen Wang, Meng-Yao Zhai, Run-Dong Wang, Qiong Shen, Wei-Li Liu, Lai-Kui
Published in
Journal of Translational Medicine
BackgroundCancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAFs’ function in oral squamous cell carcinoma (OSCC) development remains unclear. Here, we investigated the role of lysyl oxidase (LO...
